ArticleScientific reports2025
Effect of selenium nanoparticles on intestinal immunity through regulation of NLRP3 signaling pathway.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Dietary fermented orange peel and selenium nanoparticles improve antioxidant status, immunity, intestinal integrity, and growth performance in heat-stressed broilers.Poultry science · 2026Article
- Sulfated chitooligosaccharide selenium alleviates deoxynivalenol-induced intestinal injury in neonatal chicken through modulation of ULK1/LC3-mediated autophagy.Poultry science · 2026Article
- Form-specific selenium supplementation in poultry: linking bioefficacy to mechanisms and precision applications.Journal of animal science and biotechnology · 2026Review
- Article
- Effects of Echinacea Purpurea Polysaccharides on Growth Performance, Serum Biochemistry, and Intestinal Health of Immunosuppressed Broilers.Animals : an open access journal from MDPI · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This research delves into the intricate mechanisms by which Selenium nanoparticles exert their influence on intestinal health, with a focus on the modulation of NLR family pyrin domain containing 3 (NLRP3) signaling pathway. Therefore, 150 chicks were divided into three groups, which were control group, 0.2 mg/kg (low dose) and 0.4 mg/kg (high dose) Selenium nanoparticles (SeNPs) for 1 month respectively. This study showed that selenium nanoparticles effectively reduced the mortality rate of chickens. Morphological intestinal parameters were significantly reduced with increased dose of Selenium nanoparticles compared to low dose. The number of goblet cells were significantly decreased with a high dose of SeNPs. As well, the mRNA expression of Mucin2 (Muc2) significantly decreased. Compared with control group the positivity of apoptosis in the intestinal cells significantly decreased in SeNPs groups. Likewise, with high dose of SeNPs the protein and gene expression levels of Bcl-2-associated X (Bax), Caspase-3 and B-cell lymphoma-2 (Bcl-2) in small intestine significantly decreased. High dose of SeNPs significantly decreased oxidative stress and inflammation in the small intestine. High dose of SeNPs significantly decreased the toll-like receptor-2 (TLR-2), NLRP3, claudin-5 and zonula occluden-1 (ZO-1) in small intestine. The integration of scientific evidence and experimental insights will contribute to a deeper understanding of the intricate interplay between SeNPs and intestinal health, offering valuable perspectives for future research and therapeutic applications.
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Registered trials
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