Evidence map›Paper›PMID 40461502›Full record

ArticleNature communications2025

Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model.

Haley Masters, Shuxiong Wang, Christina Tu, Quy Nguyen, Yutong Sha, Matthew K Karikomi, Pamela Shi Ru Fung, Benjamin Tran, Cristina Martel, Nellie Kwang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Choroid Plexus Pathophysiology.Annual review of pathology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Haley MastersDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA.
Shuxiong WangDepartment of Mathematics, University of California Irvine, Irvine, CA, USA.
Christina TuSue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA.
Quy NguyenDepartment of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
Yutong ShaDepartment of Developmental & Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-5530-734X
Matthew K KarikomiDepartment of Mathematics, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-5149-9695
Pamela Shi Ru FungDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA.
Benjamin TranDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA.
Cristina MartelDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA.
Nellie KwangDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-8890-4976
Michael NeelDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA.
Olga G JaimeDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA.
Victoria EspericuetaDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA.
Brett A JohnsonDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-9260-245X
Kai KessenbrockDepartment of Biological Chemistry, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-0410-6104
Qing NieDepartment of Developmental & Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-8804-3368
Edwin S MonukiDepartment of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA. emonuki@uci.edu.ORCID http://orcid.org/0000-0001-5130-781X

Funding

The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9M
MINORITY BIOMEDICAL RESEARCHERS PROGRAMR25GM055246 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MOTA-BRAVO, LUIS M · 1996 to 2022
$15.3M
Training Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3M
Developing Choroid Plexus-Based Tools and Drug ScreensR21MH109036 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI JACKSON, MICHAEL, MONUKI, EDWIN S · 2016 to 2017
$459k
Human choroid plexus epithelial cells derived from APOE isogenic iPSCsR21AG064640 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MONUKI, EDWIN S · 2019 to 2020
$405k
NIA NIH HHS P30 AG066519NIA NIH HHS R21 AG064640NIGMS NIH HHS R25 GM055246NIMH NIH HHS R21 MH109036NINDS NIH HHS T32 NS082174
6 · The paper itself

Abstract

Despite the major roles of choroid plexus epithelial cells (CPECs) in brain homeostasis and repair, their developmental lineage and diversity remain undefined. In simplified differentiations from human pluripotent stem cells, derived CPECs (dCPECs) display canonical properties and dynamic motile multiciliated phenotypes that interact with Aβ uptake. Single dCPEC transcriptomes over time correlate well with human organoid and fetal CPECs, while pseudotemporal and cell cycle analyses highlight the direct CPEC origin from neuroepithelial cells. In addition, time series analyses define metabolic (type 1) and ciliogenic dCPECs (type 2) at early timepoints, followed by type 1 diversification into anabolic-secretory (type 1a) and catabolic-absorptive subtypes (type 1b) as type 2 cells contract. These temporal patterns are then confirmed in independent derivations and mapped to prenatal stages using human tissues. In addition to defining the prenatal lineage of human CPECs, these findings suggest dynamic models of ChP support for the developing human brain.

Indexed as

Choroid PlexusEpithelial CellsPluripotent Stem CellsCell DifferentiationCell LineageFemaleHumansOrganoidsTranscriptome

Identifiers

PMID40461502
PMCPMC12134268

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.