Evidence map›Paper›PMID 40461469›Full record

ArticleSchizophrenia (Heidelberg, Germany)2025

Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program.

Johanna T W Wigman, Ann Ee Ching, Yoonho Chung, Habiballah Rahimi Eichi, Erlend Lane, Carsten Langholm, Aditya Vaidyam, Andrew Jin Soo Byun, Anastasia Haidar, Jessica Hartmann and 71 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  3. Article
  4. Article
  5. Beyond RCTs-Better Research Designs and Methods for Psychosocial Efficacy Studies in Mental Health.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

81 authors.

Johanna T W WigmanUniversity of Groningen, University Medical Center Groningen, Department of Psychiatry, Interdisciplinary Centre of Psychopathology and Emotion regulation, Groningen, The Netherlands.
Ann Ee ChingCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Yoonho ChungMcLean Hospital, Belmont, MA, USA.
Habiballah Rahimi EichiMcLean Hospital, Belmont, MA, USA.
Erlend LaneBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Carsten LangholmBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Aditya VaidyamBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Andrew Jin Soo ByunBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Anastasia HaidarBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jessica HartmannOrygen, Parkville, VIC, Australia.
Angela NunezYale University, New Haven, CT, USA.
Dominic DwyerCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-3949-5867
Adibah Amani NasarudinCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Owen BordersBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Isabelle ScottCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Zailyn TamayoYale University, New Haven, CT, USA.
Priya MatnejaNorthwell Health, Glen Oaks, NY, USA.
Kang-Ik ChoHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7135-3848
Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-8298-0756
Luis K AlamedaService de Psychiatrie Générale Dép. de Psychiatrie CHUV Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-8621-2885
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.
Nicholas J K BreitbordeDepartment of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, USA.
Matthew R BroomeInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-6963-8884
Kristin S CadenheadUniversity of California, San Diego, CA, USA.
Monica E CalkinsDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0546-0263
Eric Yu Hai ChenDepartment of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.ORCID http://orcid.org/0000-0002-5247-3593
Jimmy ChoiOlin Neuropsychiatry Research Center, Hartford HealthCare Behavioral Health Network, Hartford, CT, USA.
Philippe ConusService de Psychiatrie Générale Dép. de Psychiatrie CHUV Lausanne, Lausanne, Switzerland.
Cheryl M CorcoranDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8902-4353
Barbara A CornblattDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine, Hempstead, NY, USA.
Covadonga M Diaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID http://orcid.org/0000-0001-8538-3175
Lauren M EllmanDepartment of Psychology & Neuroscience, Temple University, Philadelphia, PA, USA.
Paolo Fusar-PoliDepartment of Psychosis Studies, King's College London, London, UK.
Pablo A GasparDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.ORCID http://orcid.org/0000-0002-9682-5327
Carla GerberBehavioral Health Services, PeaceHealth Medical Group, Eugene, OR, USA.
Louise Birkedal GlenthøjCopenhagen Research Centre for Mental Health, Mental Health Copenhagen, Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Leslie E HortonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christy Lai Ming HuiDepartment of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
Joseph KambeitzDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-8988-3959
Lana Kambeitz-IlankovicDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Matcheri S KeshavanHarvard Medical School, Boston, MA, USA.
Sung-Wan KimDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.ORCID http://orcid.org/0000-0002-6739-2163
Nikolaos KoutsoulerisDepartment of Psychosis Studies, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6825-6262
Kerstin LangbeinDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Daniel MamahDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6090-4974
Vijay A MittalDepartment of Psychology, Northwestern University, Evanston, Il, USA.ORCID http://orcid.org/0000-0001-9017-5119
Merete NordentoftMental Health Services in the Capital Region, Copenhagen, Denmark.
Godfrey D PearlsonOlin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA.
Jesus PerezMcLean Hospital, Belmont, MA, USA.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-9396-2206
Albert R PowersYale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3057-5043
Jack RogersCentre for Human Brain Health, University of Birmingham, Birmingham, UK.
Fred W SabbDepartment of Psychiatry, University of Chile, Santiago, Chile.
Jason SchiffmanDepartment of Psychological Science, University of California, Irvine, CA, USA.
Jai L ShahPEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-7549-6990
Steven M SilversteinDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-0699-0960
Stefan SmesnyDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Walid YassinHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9612-0485
William S StoneHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2932-7288
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA, USA.
Judy L ThompsonDepartment of Psychiatry, University of Rochester Medical Center, Rochester, New York, USA.
Rachel UpthegroveInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Swapna VermaInstitute of Mental Health, Singapore, Singapore.
Jijun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Daniel H WolfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9731-8781
Phillip WolffDepartment of Psychology, Emory University, Atlanta, GA, USA.
Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
Laura M RowlandNational Institute of Mental Health, Bethesda, MD, USA.
Simon D'AlfonsoSchool of Computing and Information Systems, The University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0001-7407-8730
Ofer PasternakBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sylvain BouixBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1326-6054
Patrick D McGorryCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Rene S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John M KaneDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine, Hempstead, NY, USA.
Carrie E BeardenDepartments of Psychiatry and Biobehavioral Sciences & Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8516-923X
Scott W WoodsYale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3103-5228
Martha E ShentonHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4235-7879
Barnaby NelsonCentre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Justin T Baker *McLean Hospital, Belmont, MA, USA.
John Torous *Harvard Medical School, Boston, MA, USA. jtorous@bidmc.harvard.edu.ORCID http://orcid.org/0000-0002-5362-7937

Funding

ProNET: Psychosis-Risk Outcomes NetworkU01MH124639 · NIMH · YALE UNIVERSITY · PI CARRIE E BEARDEN, JOHN M KANE · 2020 to 2026
$81.2M
Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination CenterU24MH124629 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Rene S. Kahn, Martha E. Shenton · 2020 to 2026
$32.6M
Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)U01MH124631 · NIMH · UNIVERSITY OF MELBOURNE · PI Christopher Barnaby Nelson · 2020 to 2026
$30.4M
NIMH NIH HHS U01 MH124631NIMH NIH HHS U01 MH124639NIMH NIH HHS U24 MH124629Wellcome Trust
6 · The paper itself

Abstract

Although meta-analytic studies have shown that 25-33% of those at Clinical High Risk (CHR) for psychosis transition to a first episode of psychosis within three years, less is known about estimating the risk of transition at an individual level. Digital phenotyping offers a novel approach to explore the nature of CHR and may help to improve personalized risk prediction. Specifically, digital data enable detailed mapping of experiences, moods and behaviors during longer periods of time (e.g., weeks, months) and offer more insight into patterns over time at the individual level across their routine daily life. However, while novel digital health technologies open up many new avenues of research, they also come with specific challenges, including replicability of results and the adherence of participants. This paper outlines the design of the digital component of the Accelerating Medicines Partnership® Schizophrenia Program (AMP SCZ) project, a large international collaborative project that follows individuals at CHR for psychosis over a period of two years. The digital component comprises one-year smartphone-based digital phenotyping and actigraphy. Smartphone-based digital phenotyping includes 30-item short daily self-report surveys and voice diaries as well as passive data capture (geolocation, on/off screen state, and accelerometer). Actigraphy data are collected via an Axivity wristwatch. The aim of this paper is to describe the design and the three goals of the digital measures used in AMP SCZ to: (i) better understand the symptoms, real-life experiences, and behaviors of those at CHR for psychosis, (ii) improve the prediction of transition to psychosis and other health outcomes in this population based on digital phenotyping and, (iii) serve as an example for replicable and ethical research across geographically diverse regions and cultures. Accordingly, we describe the rationale, protocol and implementation of these digital components of the AMP SCZ project. **Link to video interview: https://vimeo.com/1060935583 *.

Identifiers

PMID40461469
PMCPMC12134270

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.