Evidence map›Paper›PMID 40461421›Full record

ArticleJournal of veterinary science2025

Epidemiological investigation and fiber gene genetic analysis of fowl adenovirus serotype 4 from 2017 to 2021 in Yunnan Province, China.

Xiaoyan Xue, Zhenxing Zhang, Qinhong Yang, Wei Wang, Jianling Song

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Article in Journal of veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoyan Xue *College of Life Sciences, Southwest Forestry University, Kunming 650024, China.ORCID https://orcid.org/0009-0003-5584-6484
Zhenxing Zhang *Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Academy of Animal Husbandry and Veterinary, Kunming 650224, China.ORCID https://orcid.org/0009-0001-4417-6791
Qinhong YangCollege of Life Sciences, Southwest Forestry University, Kunming 650024, China.ORCID https://orcid.org/0009-0003-0721-8731
Wei WangCollege of Life Sciences, Southwest Forestry University, Kunming 650024, China.ORCID https://orcid.org/0009-0009-0549-3936
Jianling SongYunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Academy of Animal Husbandry and Veterinary, Kunming 650224, China. jianling_song@hotmail.com.ORCID https://orcid.org/0000-0002-2961-5119

Funding

Epitope localization of avian adenovirus type 4 and molecular mechanism of AS-ONs inhibiting infection 202301AS070006Yunnan Center for Animal Disease Control and Prevention 1963037Yunnan Provincial Applied Basic Research Plan 2016FA013
6 · The paper itself

Abstract

importanceThrough the epidemiological survey of fowl adenovirus serotype 4 (FAdV-4) in poultry and wild birds in Yunnan Province from 2017 to 2021, this study provides a scientific basis for the prevention and control of FAdV-4 in the region. Currently, there is a lack of monitoring and epidemiological research on FAdV-4 in wild birds in China, offering valuable insights for future studies on the virus in wild populations. Additionally, the analysis of the fiber gene sequence of FAdV-4 identified the prevalent strains in Yunnan Province, which lays the groundwork for future treatment and prevention strategies.

objectiveThis study aimed to understand the epidemic situation of FAdV-4 in Yunnan Province and provide a reference for the prevention and control of the infection.

methodsSuspected samples of FAdV-4 were collected with the wild birds from overwintering habitat and naturally dying poultry from poultry farms in Yunnan Province, and polymerase chain reaction (PCR) detection of FAdV-4 and related co-infection pathogens, pathogen isolation, and genetic evolution analysis of the

resultsThe results showed that the FAdV-4 positive rate in poultry and migratory birds was 11.3% and 0.3%, respectively. The infection rate of the poultry tissue samples was high in central and western Yunnan Province. The detection of common poultry infectious diseases prone to co-infection, it was found that the birds were mainly co-infected with pathogens such as infectious laryngotracheitis, chicken infectious anemia virus, and avian influenza virus. Five poultry-source strains and one wild bird-source strain were isolated, and phylogenetic analysis showed that they all had high homology with the early Chinese highly pathogenic strains and clustered with the same genetic and evolutionary clade as the Chinese reference strain. The fiber protein is characterized by loci that indicate highly pathogenic strains (G219D, P307A, V319I, and A308T). CONCLUSIONS AND RELEVANCE: The results of our study demonstrate that FAdV-4 continues to exhibit a high prevalence rate among poultry populations in Yunnan Province, China. Notably, we report the first detection of FAdV-4 in the feces of black-necked cranes.

Indexed as

Adenoviridae InfectionsAviadenovirusBird DiseasesCapsid ProteinsPoultry DiseasesAnimalsAnimals, WildBirdsChickensChinaPhylogenyPrevalenceSerogroupCapsid Proteinsco-infectionepidemiologyFAdV-4fiberinfection rate

Identifiers

PMID40461421
PMCPMC12146020

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