Evidence map›Paper›PMID 40461274›Full record

ArticleJournal of the American Chemical Society2025

Click-Controlled Photo-Uncaging: Click-Assembly of Platinum-Based Photoactive Protecting Groups for Light-Triggered Bioactive Molecule Release.

Arpit Sharma, Wjdan Jogadi, Man Kshetri, Suha Alqarni, Md Al Amin, May Cheline, Bishal Pokhrel, Shirin Akter, Zexin Lin, Jimin Park and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Arpit SharmaDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Wjdan JogadiDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Man KshetriDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Suha AlqarniDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Md Al AminDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
May ChelineDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.ORCID 0000-0001-6768-9197
Bishal PokhrelDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Shirin AkterDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.ORCID 0009-0001-0158-8091
Zexin LinDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.ORCID 0009-0001-4164-4713
Jimin ParkDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Jordan SolmenDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Jordan CarawayDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Megan BrattleyDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Hao ShenDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.ORCID 0000-0002-2798-5861
Yao-Rong ZhengDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.ORCID 0000-0003-4605-1121

Funding

Development of Novel Metal-Based Supramolecular Therapeutics for Ovarian CancerR15CA249712 · NCI · KENT STATE UNIVERSITY · PI ZHENG, YAORONG · 2021 to 2021
$455k
Light-Controlled Supramolecular Platinum Complexes for Biomedical ApplicationsR15GM152919 · NIGMS · KENT STATE UNIVERSITY · PI ZHENG, YAORONG · 2024 to 2024
$434k
NCI NIH HHS R15 CA249712NIGMS NIH HHS R15 GM152919
6 · The paper itself

Abstract

We introduce click-controlled photouncaging, an innovative approach that synergizes click ligation with photocleavage to achieve biorthogonal, light-triggered bioactive molecule release across visible to near-infrared (NIR) wavelengths. Central to this approach is a novel amine protection and deprotection strategy utilizing Pt(IV) complexes. In this strategy, an azide-bearing clickable Pt(IV) moiety acts as a protecting group for amine-containing molecules (the ″cargo″) via a carbamate linkage. Subsequently, click ligation with a DBCO-tagged fluorescent antenna positions the antenna near the Pt(IV) core, transforming it into a photoactive protecting group (PPG) that can be fine-tuned to respond to visible or NIR light. When exposed to light, the antenna drives the photoreduction of the Pt(IV) linker, triggering deprotection and subsequently releasing the cargo molecule. To validate this approach, three Pt(IV) complexes were synthesized featuring amine-containing fluorescent reporters (coumarin, BODIPY) and a therapeutic molecule (Exatecan), and their functionality was validated in solution and cell cultures. Overall, this work introduces a novel, user-friendly, and versatile chemical tool for bioorthogonal, light-controlled activation of molecules in complex biological environments.

Indexed as

Antineoplastic AgentsLightOrganoplatinum CompoundsPlatinumAzidesClick ChemistryHumansInfrared RaysMolecular StructurePhotochemical ProcessesAntineoplastic AgentsAzidesOrganoplatinum CompoundsPlatinum

Identifiers

PMID40461274
PMCPMC13060532

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.