ArticleAJNR. American journal of neuroradiology2025
Association of MRI-Visible Perivascular Spaces with Early White Matter Injury.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Retinal Optical Coherence Tomography-Angiography and Longitudinal Changes in Cognition and Cerebral Small Vessel Disease.Neurology · 2026Article
- Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Enlarged Perivascular Spaces Among Hispanic and Latino Adults in SOL-INCA-MRI.Journal of the American Heart Association · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
background and purposeMRI-visible perivascular spaces (PVS) are considered markers of cerebral small vessel disease (CSVD) and may reflect dysfunction of brain perivascular drainage. WM integrity assessed with DTI provides a sensitive assessment of early brain injury, related vascular risk factors, and risk of stroke and dementia. We investigated the relationship between PVS and WM integrity in community-dwelling participants. MATERIALS AND
methodsFramingham Heart Study (FHS) participants with brain MRI, PVS ratings, and DTI measures were included. PVS were rated in the basal ganglia (BG) and centrum semiovale (CS) and categorized into grades I-IV based on counts. We related PVS burden to global DTI measures (free water fraction [FW], fractional anisotropy [FA], peak skeletonized mean diffusivity [PSMD]), diffusion along perivascular spaces (DTI-ALPS), and voxel-based measures using multivariable linear regression analyses.
resultsAmong 3077 participants (57.2 mean age; 53% women), 7% had high-burden PVS in the BG, and 13% had high burden in the CS. High PVS burden in either or both regions was associated with higher global FW, PSMD, lower global FA, and lower DTI-ALPS index in fully adjusted models (
conclusionsPVS burden was associated with early signs of global WM injury after adjustment for vascular risk factors, suggesting that high PVS burden may represent early brain injury related to CSVD or impaired perivascular function.
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