Evidence map›Paper›PMID 40461179›Full record

ReviewJournal of sleep research2025

Isolated REM Sleep Behaviour Disorder-Is Screening Possible?

Matteo Cesari, Andreas Brink-Kjaer, Emmanuel During, Wolfgang Ganglberger, Oriella Gnarra, Bei Huang, Michael Sommerauer, Pietro Luca Ratti, Irene Rechichi, Yun Kwok Wing and 1 more

Abstract readReview
In one paragraph

Review in Journal of sleep research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. A gradual and sustainable approach to diagnosing sleep and circadian disturbances in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matteo CesariDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0001-6554-1033
Andreas Brink-KjaerDepartment of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.
Emmanuel DuringDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Wolfgang GanglbergerDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0002-6029-2450
Oriella GnarraDepartment of Health Science and Technologies, Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, Switzerland.
Bei HuangLi Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China.
Michael SommerauerCenter of Neurology, Department of Parkinson, Sleep and Movement Disorders, University of Bonn, Bonn, Germany.
Pietro Luca RattiNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Irene RechichiDepartment of Control and Computer Engineering, Politecnico di Torino, Turin, Italy.ORCID 0000-0002-9420-4922
Yun Kwok WingLi Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-5745-5474
Ambra StefaniDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-4259-8824

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia characterised by the loss of muscle atonia during REM sleep and dream-enacting behaviours. In its isolated form (iRBD) it is widely recognised as an early stage of alpha-synucleinopathies. Early identification of patients with iRBD allows for timely interventions, risk mitigation and potential inclusion in clinical trials aimed at disease modification. Effective screening tools, including questionnaires, automatic analyses of video-polysomnography, actigraphy, nearables and biological markers, can facilitate diagnosis and monitoring. Incorporating routine screening into clinical practice may enhance early detection and improve long-term patient outcomes. This manuscript presents the latest developments in screening tools for the identification of patients with iRBD and discusses their advantages and drawbacks, highlighting paths for future research and applications.

Indexed as

Mass ScreeningREM Sleep Behavior DisorderActigraphyHumansPolysomnographySurveys and QuestionnairesiRBDprodromal alpha‐synucleinopathyRBDscreening tool

Identifiers

PMID40461179
PMCPMC12426715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.