Evidence map›Paper›PMID 40461050›Full record

ArticleACS applied materials & interfaces2025

Targeted Peptide Nanofiber-Loaded Stomatocytes for Combined Photodynamic and Photothermal Therapy.

Yuechi Liu, Duc H T Le, Gokhan Yilmaz, Lars Paffen, Shukun Li, Alexander B Cook, Tania Patino Padial, Loai Abdelmohsen, C Remzi Becer, Bingbing Sun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuechi LiuBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Helix, The Netherlands.
Duc H T LeBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Helix, The Netherlands.
Gokhan YilmazDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
Lars PaffenBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Helix, The Netherlands.ORCID 0009-0002-0218-6403
Shukun LiBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Helix, The Netherlands.
Alexander B CookBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Helix, The Netherlands.ORCID 0000-0002-5005-1039
Tania Patino PadialBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Helix, The Netherlands.
Loai AbdelmohsenBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Helix, The Netherlands.ORCID 0000-0002-0094-1893
C Remzi BecerDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.ORCID 0000-0003-0968-6662
Bingbing SunBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Helix, The Netherlands.
Jan C M van HestBio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Helix, The Netherlands.ORCID 0000-0001-7973-2404

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanotechnology-based photodynamic (PDT) and photothermal (PTT) therapies offer precise treatment by generating reactive oxygen species (ROS) and localized hyperthermia. However, photosensitizer nanodrugs suffer from rapid degradation and limited tumor targeting. To overcome these challenges, we have developed a dual-nanoparticle drug delivery platform based on bowl-shaped polymer vesicles, which were loaded in the protective nanocavity with nanofibers composed of a histidine dipeptide-photosensitizer conjugate. The stomatocytes were surface modified with mannose glycopolymers to induce targeting capacity. This dual nanoparticle platform exhibited enhanced tumor imaging, improved targeting, and increased cellular uptake in tumor cells and 3D tumor spheroids. Under 660 nm laser irradiation, it demonstrated excellent PTT and PDT performance, with significant ROS generation and temperature elevation. This advanced nanomedicine platform, therefore, offers a promising approach for precision cancer therapy.

Indexed as

NanofibersPeptidesPhotochemotherapyPhotosensitizing AgentsPhotothermal TherapyAnimalsCell Line, TumorDrug Delivery SystemsHumansMiceReactive Oxygen SpeciesPeptidesPhotosensitizing AgentsReactive Oxygen Speciesglycopolymernanofiberpeptide conjugatesphotodynamic therapystomatocytes

Identifiers

PMID40461050
PMCPMC12186217

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.