ArticleMagnetic resonance imaging2025
Comprehensive characterization of tumor therapeutic response via simultaneous mapping of cell size, density, and transcytolemmal water exchange.
Article in Magnetic resonance imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The predictive value of MR cytometry in histological differentiation of rectal cancer: an exploratory study.European radiology · 2026Observational
- Quantifying Transmembrane Water Exchange by Diffusion NMR Methods: From Yeast Cells to Optic Nerve Ex Vivo.NMR in biomedicine · 2026Article
- MRI cytometry imaging for cervical cancer differential diagnosis: a preliminary study.BMC medical imaging · 2025Article
- Comparison of MR cytometry methods in predicting immunohistochemical factor status and molecular subtypes of breast cancer.Radiology and oncology · 2025Article
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9 authors.
Funding
Abstract
The evaluation of tumor response to neoadjuvant chemotherapy is critical for the personalized management of cancer patients, aiming to minimize unnecessary toxicity, costs, and treatment delays. Current imaging techniques primarily depend on detecting tumor volume changes, which reflect downstream effects. In contrast, advanced microstructural diffusion MRI (dMRI) methods offer cellular-level insights but are limited by biased estimates of cell density due to oversimplified biophysical models. We present a novel dMRI-based approach, EXCHANGE, which incorporates transcytolemmal water exchange into a quantitative multi-compartmental biophysical model. This method enables simultaneous mapping of cell size, density, and transcytolemmal water exchange, providing a comprehensive characterization of tumor microstructure. Validation through computer simulations and in vitro studies demonstrated the good accuracy of EXCHANGE-derived metrics. In a proof-of-concept study, EXCHANGE was applied to animal models and patients with triple-negative breast cancer, showcasing its potential to evaluate tumor therapeutic response to neoadjuvant chemotherapy. EXCHANGE offers a unique capability to characterize tumor microstructural properties at the cellular level, paving the way for improved monitoring of treatment response in clinical settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.