ArticleJournal of advanced research2026
A cocktail hydrogel promoting the functional interneurons regeneration of human neural progenitor cells for brain injury therapy.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Molecular Basis of Glia-ECM Interplay in Central Nervous System Homeostasis and Plasticity.Cells · 2026Review
- Dynamic Tuning of MSC-Based Scaffolds for Neurological Protection After Brain or CNS Injury.Life (Basel, Switzerland) · 2026Review
- Innovative Biomaterials for Modulating Neuroinflammation and Promoting Repair After Traumatic Brain Injury.Pharmaceutics · 2026Review
- Artificial intelligence-driven nano-enhanced stem cell therapy for neurodegenerative diseases: from rational design to clinical translation.Journal of nanobiotechnology · 2026Review
- Aerogel library with varying porous structures and mechanics regulates motor neuron progenitor differentiation for spinal cord injury repair.Materials today. Bio · 2025Article
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Authors and funding
22 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionTraumatic Brain Injury (TBI) usually leads to substantial mortality and disability among adult populations. Neural progenitor cells (NPCs) transplantation exhibits great potential in TBI treatment. However, the differentiation rate of interneurons is relatively low, largely impeding the therapeutic effects of brain tissue repair.
objectivesA cocktail hydrogel (BGA@GelMA) was developed to provide a sustained release of neurotrophic factors and neural signaling molecules, thereby promoting the maturation of cortical interneurons, which can be utilized to improve the therapeutic outcomes of hNPCs transplantation for cerebral injury treatment.
methodsThe cocktail strategy (BGA@GelMA) was developed by integrating a hydrogel with neural inducers, and was characterized using cryogenic scanning electron microscopy (cryo-SEM), rheological tests and release kinetics. The potential of the BGA@GelMA hydrogel to differentiate hNPCs into cortical interneurons and to facilitate neural networks formation was analyzed with transcriptomic analysis, transsynaptic rabies virus tracing, flow cytometric analysis, immunofluorescence staining, and quantitative reverse transcription polymerase chain reaction (RT-qPCR). To enhance the efficiency of cell-based therapies, human pluripotent stem cells (hPSCs)-derived hNPCs encapsulated within the BGA@GelMA hydrogel were transplanted into a rat TBI model. The brain tissue repair was assessed using hematoxylin and eosin (H&E) staining, immunofluorescence staining, magnetic resonance imaging (MRI), motor evoked potential (MEP) recordings, and behavior tests.
resultsThe synergistic role of micro- and nano-characterization, mechanical properties and multiple inducers-rich environment facilitated the maturation of cortical interneurons and the formation of synapses. Furthermore, after transplantation into the motor cortex of a rat TBI model, hNPCs embedded within BGA@GelMA hydrogel successfully enhanced brain recovery by differentiating into cortical interneurons, reducing the inflammatory response, and regenerating Neurovascular-like Unit (NVU).
conclusionThis cocktail hydrogel provided a novel strategy for improving the effect of hNPCs transplantation for cerebral injury treatment.
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