ArticleJournal of the neurological sciences2025
Low-density lipoprotein cholesterol and severity of intracerebral hemorrhage: Insights from the SIREN study.
Article in Journal of the neurological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Funding
Abstract
backgroundWe investigated the link between LDL-C and markers of ICH severity among Indigenous West Africans in the Stroke Investigative Research and Education Network study.
methodsICH severity was evaluated using the Glasgow Coma Scale (GCS), Stroke Levity Scale (SLS), and the National Institutes of Health Stroke Scale (NIHSS). The serum LDL-c of the study population was dichotomized into <133 mg/dl and ≥ 133 mg/dl using the optimum threshold by the Youden Index after assessing the linear relationship between the serum LDL-c measured at admission and ICH severity markers. A multivariate-adjusted logistic regression was performed to identify the independent association of serum LDL-C with ICH severity.
resultsOverall, 959 subjects were investigated, with a mean age of 53.9 ± 13.24 years; 62.7 % were men with GCS median (IQR) of 8.0 (12.0,15.0), SLS of 5.0 (2.0,8.0) and NIHSS of 15.0 (8.0,23.0). The mean ± SD LDL-C was 124.78 ± 51.8 mg/dl and the baseline serum LDL-C showed a positive linear relationship with admitting GCS and SLS scores and a negative relationship with the NIHSS score. Patients with LDL < 133 mg/dl had more severe stroke [SLS median (IQR): 5.0(2.0,8.0] and GCS median (IQR):11.0(7.0,15.0] compared to patients with LDL-C ≥ 133 mg/dl. Systolic BP ≥ 140 mmHg [1.720 (1.168,2.532)], ICH volume ≥ 30mls [2.774(1.990,3.865)], presence of intraventricular extension [1.564 (1.158, 2.113)] and serum LDL-C < 133 mg/dl [1.502 (1.110, 2.032)] were independently associated with severe ICH. In the subgroup analysis, the independent association between serum LDL-C < 133 mg/dl and severe ICH was stronger for subjects <50 years [1.690 (1.017, 2.808)] and males [1.621 (1.092, 2.406)].
conclusionLow serum LDL-C is independently associated with severe ICH among West Africans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.