ArticlePloS one2025
Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential predictors of nosocomial infection in patients undergoing veno-arterial extracorporeal membrane oxygenation: A cohort study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate and compare the predictive value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for nosocomial infection in patients undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO).
methodsIn this retrospective cohort study, we assessed 95 patients who underwent VA-ECMO between 2018 and 2023 at the Third People's Hospital of Henan Province. The association between NLR, PLR and nosocomial infection in patients undergoing VA-ECMO was tested using logistic regression model.
resultsAmong 95 VA-ECMO patients, 30 were found to have developed nosocomial infection (infection rate 31.58%). Patients with higher levels of NLR and PLR showed higher rates of nosocomial infections (p < 0.05). Higher NLR were associated with an increased risk of nosocomial infections in patients undergoing VA-ECMO (odds ratio [OR], 4.858; 95% confidence interval [95% CI], 1.864-12.663) (P = 0.001), after adjusting for sex, age, hemoglobin, albumin, and duration of VA-ECMO treatment. In reference to the first tertile of NLR, ORs were 6.931 (95% CI, 1.496-32.118) for the second tertile, 8.898 (95% CI, 1.943-40.751) for the third tertile. PLR was a risk factor for nosocomial infections in patients undergoing VA-ECMO (OR 5.478; 95%CI 2.117-14.176) after adjusting for traditional risk factors (P < 0.001). ROC curve analysis showed that the area under the curve (AUC) of NLR and PLR to predict nosocomial infections in patients treated with VA-ECMO were 0.710 and 0.763, respectively.
conclusionsHigh NLR and PLR were associated with an increased risk of nosocomial infection in patients treated with VA-ECMO.
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