Evidence map›Paper›PMID 40460200›Full record

ArticleCell reports2025

KMT2D coordinates antiviral CD4

Jonathan A Cohen, Ashlyn A Buzzelli, Gabrielle Quickstad, Lixin Yang, Ichiro Misumi, Karl B Shpargel, Jason K Whitmire

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Clonal selection of somatic mutations shapes NK cell memory.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan A CohenDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Ashlyn A BuzzelliDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Gabrielle QuickstadDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Lixin YangDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Ichiro MisumiDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Karl B ShpargelDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
Jason K WhitmireDepartment of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: jwhitmir@email.unc.edu.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
UNC Medical Scientist Training ProgramT32GM152316 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Toni Darville, Mohanish P Deshmukh · 2024 to 2026
$4.3M
Regulation of CD8+ T cell responses to chronic virus infectionR01AI143894 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2019 to 2023
$2.5M
Obesity associated viral pathogenesisR01AI138337 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2018 to 2022
$1.9M
Murine Model of Human Hepatitis AR01AI131685 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEMON, STANLEY M., WHITMIRE, JASON KYLE · 2017 to 2021
$1.9M
Enhancer activation mechanisms in cranial neural crest osteoblast differentiationR01DE030530 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHPARGEL, KARL BRYAN · 2021 to 2024
$1.4M
NCI NIH HHS P30 CA016086NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS R01 AI131685NIAID NIH HHS R01 AI138337NIAID NIH HHS R01 AI143894NIDA NIH HHS 75N95020D00005NIDCR NIH HHS R01 DE030530NIDDK NIH HHS P30 DK034987NIGMS NIH HHS T32 GM152316ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

T follicular helper (T

Indexed as

CD4-Positive T-LymphocytesHistone-Lysine N-MethyltransferaseT Follicular Helper CellsT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerAnimalsCD8-Positive T-LymphocytesGene Expression RegulationHistonesInterleukin-21InterleukinsLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutHistone-Lysine N-MethyltransferaseHistonesInterleukin-21InterleukinsKmt2d protein, mouseMyeloid-Lymphoid Leukemia Proteinantiviral T cellsCD4(+) T cellsCD8(+) T cellsCP: GenomicsCP: Immunologycytolytic CD4(+) T cellsepigeneticsKMT2DLCMVmouseT follicular helper cellsTh1 cells

Identifiers

PMID40460200
PMCPMC12302258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.