Evidence map›Paper›PMID 40460178›Full record

ArticlePloS one2025

Structural determinants of inequalities in untreated dental caries in the Global Burden of Disease Study.

Orlando Luiz do Amaral Junior, Maria Laura Braccini Fagundes, Fernando Neves Hugo, Nicholas J Kassebaum, Jessye Melgarejo do Amaral Giordani

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Association of clinical consequences of untreated caries in early childhood with oral health-related quality of life.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2026
    Article
  3. Article
  4. Article
  5. A biomimetic urchin-like photothermal nanoplatform for the efficient eradication ofFrontiers in cellular and infection microbiology · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Orlando Luiz do Amaral JuniorPostgraduate Program in Dental Sciences, Federal University of Santa Maria, Santa Maria, Brazil.ORCID https://orcid.org/0000-0002-6611-3871
Maria Laura Braccini FagundesPostgraduate Program in Dental Sciences, Federal University of Santa Maria, Santa Maria, Brazil.
Fernando Neves HugoCollege of Dentistry, Department of Epidemiology and Health Promotion, New York University, New York, New York, United States of America.ORCID https://orcid.org/0009-0000-4029-4558
Nicholas J KassebaumInstitute for Health Metrics and Evaluation, University of Washington, Seattle, United States of America.
Jessye Melgarejo do Amaral GiordaniPostgraduate Program in Dental Sciences, Federal University of Santa Maria, Santa Maria, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUntreated dental caries remains a significant global public health challenge, disproportionately affecting vulnerable populations and highlighting inequalities in health systems worldwide. Examining its distribution across diverse contexts is essential for guiding targeted interventions, informing public policies, and allocating resources more effectively. This study aims to provide a comprehensive global assessment of the distribution of untreated dental caries in 204 countries and territories, spanning the years 2000, 2010, and 2019, by dimensions of structural determinants of health.

methodsThis study employs an ecological design. This analysis describes the incidence, prevalence and years lived with disability (YLDs) due to untreated dental caries in permanent and deciduous teeth by structural determinants of health (dimensions of governance, macroeconomic policy, social policy, public policies and culture/societal values), for 204 countries and territories. Estimates of untreated caries in deciduous teeth by structural determinants were reported for children under 5 years of age, whereas estimates in permanent teeth were described for adolescents and adults aged between 15 and 49 years. Estimates were retrieved from the Global Health Data Exchange.

resultsThere was a gradient of inequality between countries in terms of prevalence, YLDs, and the incidence of overt untreated caries. Countries that had better structural indicators had lower mean prevalence of untreated caries in primary teeth. In the permanent dentition, between-countries inequalities were not identified. Additionally, the mean prevalence was stable from 2010 to 2019.

conclusionsThis study revealed possible cross-country inequalities in the burden of untreated caries in deciduous teeth that persisted over one decade. More developed countries experienced less disease burden. These findings show the need for targeted interventions to address the uneven burden of untreated dental caries worldwide. CLINICAL SIGNIFICANCE: This study underscores the need for targeted global health policies to reduce untreated dental caries, especially in countries with lower structural health determinants, highlighting cross-country inequalities in disease burden and the importance of addressing these disparities in both primary and permanent dentition.

Indexed as

Dental CariesGlobal Burden of DiseaseAdolescentAdultChildChild, PreschoolFemaleGlobal HealthHumansIncidenceInfantMaleMiddle AgedPrevalenceSocioeconomic FactorsYoung Adult

Identifiers

PMID40460178
PMCPMC12132969

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.