ArticlePloS one2025
Diversity analysis of oral and gut microbiota in osteoporotic rats.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Research Progress on Mechanisms of Milk-Derived Functional Components in Regulating Bone Health and the Gut-Bone Axis.Nutrients · 2026Review
- Oral microbiome-SASP-aging axis: mechanisms and targeted intervention strategies for age-related diseases.Journal of oral microbiology · 2026Review
- Battery pollutant leakage disrupts antioxidant ability and gut microbial homeostasis of chickens.Frontiers in cellular and infection microbiology · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral and gut microbiota had been shown to control bone metabolism and have a strong correlation with osteoporosis. However, to reveal the oral and gut bacteria characteristics in osteoporosis, further studies are still needed to investigate the relationship between oral and gut microbiota diversity and bone health in OVX-induced osteoporotic rats versus Sham-operated (Sham) rats. This study analyzed the oral and gut microbiota in OVX and Sham rats using 16S rRNA gene sequencing. We compared microbial diversity and composition between the two groups. There was an inverse association found between the number of bacterial taxa and bone mineral density (BMD) readings. The OVX group had considerably higher estimated diversity of both oral and gut microbiota than the Sham group. Firmicutes, Bacteroidota, Proteobacteria, and Actinobacteriota were the dominant phyla in both groups. The OVX group had a reduced ratio of Firmicutes in oral and gut microbiota compared to the Sham group (p < 0.05). OVX rats had a higher proportion of oral Bacteroidota but a lower proportion of gut microbiota. They also had a substantial drop in Lactobacillus in both oral and gut microflora (p < 0.01). The crosstalk between oral and gut microbiota may be important in the development of osteoporosis. Identifying novel biomarkers in the oral and gut microbiota could provide more information in osteoporosis and the intricate oral-gut-bone health interaction.
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