ArticleProceedings of the National Academy of Sciences of the United States of America2025
Convergent expansions of keystone gene families drive metabolic innovation in Saccharomycotina yeasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Article
- Article
- The genetic foundations of convergent traits.Nature reviews. Genetics · 2026Review
- Evolutionary causes and consequences of gene duplication.Nature reviews. Genetics · 2026Review
- Polyploidy: A macromutational force pushing bioeconomic developments.Proceedings of the National Academy of Sciences of the United States of America · 2026Review
- Chromosome-Level Genome Assembly of the Allotetraploid Gynostemma pentaphyllum Provides Novel Insights Into the Biosynthesis of Ginsenoside and Gypenoside LVI.Plant biotechnology journal · 2026Article
- Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes.The EMBO journal · 2026Article
- Soudanones H and I from a freshwater fungusTetrahedron letters · 2026Article
- The macroevolution of filamentation morphology across the Saccharomycotina yeast subphylum.FEMS yeast research · 2026Article
- Characterizing and mitigating confounding by unreplicated evolutionary events in phylogenetic regression.bioRxiv : the preprint server for biology · 2025Article
- The Macroevolution of Filamentation Morphology Across thebioRxiv : the preprint server for biology · 2025Article
- Genomic and phenotypic insights into the expanding phylogenetic landscape of the Cryptococcus genus.PLoS genetics · 2025Article
- Genomic and phenotypic insights into the expanding phylogenetic landscape of thebioRxiv : the preprint server for biology · 2025Article
- Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes.bioRxiv : the preprint server for biology · 2025Article
- Discovery of additional ancient genome duplications in yeasts.bioRxiv : the preprint server for biology · 2025Article
- Convergent expansions of keystone gene families drive metabolic innovation in Saccharomycotina yeasts.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Specialization Restricts the Evolutionary Paths Available to Yeast Sugar Transporters.Molecular biology and evolution · 2024Article
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Abstract
Many remarkable phenotypes have repeatedly occurred across vast evolutionary distances. When convergent traits emerge on the tree of life, they are sometimes driven by the same underlying gene families, while other times, many different gene families are involved. Conversely, a gene family may be repeatedly recruited for a single trait or many different traits. To understand the general rules governing convergence at both genomic and phenotypic levels, we systematically tested associations between 56 binary metabolic traits and gene count in 14,785 gene families from 993 Saccharomycotina yeasts. Using a recently developed phylogenetic approach that reduces spurious correlations, we found that gene family expansion and contraction were significantly linked to trait gain and loss in 45/56 (80%) traits. While 595/739 (81%) significant gene families were associated with only one trait, we also identified several "keystone" gene families that were significantly associated with up to 13/56 (23%) of all traits. Strikingly, most of these families are known to encode metabolic enzymes and transporters, including all members of the industrially relevant
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