ArticlePloS one2025
Children as controls in research; The voice of the volunteer.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Public participation in child health: the Healthy Infants and Children Clinical Research Program (HICCUP).Pediatric research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundModern paediatric healthcare is increasingly dependent on diagnostic methods such as imaging and blood samples. These methods require knowledge of physiology and anatomy to separate signs of early disease development from physiological variants. To acquire this knowledge, researchers depend on studies on children from the general populations, but little is known about how children and their guardians experience participation in studies. This study aims to map the experiences of children participating in research. MATERIALS AND
methodsFrom a cohort of children and guardians from the general population, participating as controls in a large study on juvenile idiopathic arthritis (NorJIA), a subset was invited to share their experiences. The participants were examined using blood sampling, MRI, x-ray, bone-density scan, anthropometric measurements, and questionnaires. A questionnaire of 26 questions regarding their experiences from the study was sent out 2-4 weeks after the data collection.
resultsThe questionnaire was filled out by 50 children and 50 guardians. A large majority of the children responded that they were positive to help researchers, that blood sample procedures and imaging procedures went well, that they would participate in the study again, and would recommend their friends to take part in similar studies. Guardians generally responded positively, but there were diverging responses between children and guardians.
conclusionChildren from the general population reported mainly positive experiences from participation in research, including imaging and blood sampling. The experiences of the children and their guardians are sometimes diverging, underpinning the importance of addressing the child's opinions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.