ArticleAnalytical chemistry2025
Hydrodynamic Chromatography with Deterministic Lateral Displacement Effect.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hydrodynamic chromatography (HDC) is a flow-driven passive method for separating micrometric/nanometric particles based on the interaction between a nonuniform velocity profile and Brownian diffusion, which causes particles of different size to migrate at different average velocity throughout the separation column. Despite its conceptual simplicity and relative ease of implementation, HDC remains to date an underutilized technique in view of the lengthy channels and large operational times required. In the search for optimal geometries enhancing separation efficiency, micro-Pillar Array Columns (μPACs), constituted by a doubly periodic obstacle lattice aligned with the direction of the flow, have been successfully proposed and tested. The aim of this article is to show that a further improvement of HDC efficiency in μPACs is possible by enforcing a symmetry breakup, where the lattice is misaligned by an angle θ
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Registered trials
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