ArticleACS infectious diseases2025
Metabolic Activation versus Masked Prodrugs: Bisubstrate Mimic Inhibitors of CoaBC's PPCS Activity in
Timothy J Kotzé, Konrad J Mostert, Riyad Domingo, Xu Wang, Wessel J A Moolman, Hailey S Butman, Abigail Pepin, Kyle T McKay, Deon P Neveling, Joanna C Evans and 4 more
Abstract read
In one paragraphArticle in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Timothy J KotzéDepartment of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa.
Konrad J MostertDepartment of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa.ORCID 0000-0001-6223-3393 Riyad DomingoDepartment of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa.
Xu WangDepartment of Chemistry, The George Washington University, Washington DC 20052, United States.ORCID 0000-0001-7379-5789 Wessel J A MoolmanDepartment of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa.
Hailey S ButmanDepartment of Chemistry, The George Washington University, Washington DC 20052, United States.
Abigail PepinDepartment of Chemistry, The George Washington University, Washington DC 20052, United States.
Kyle T McKayDepartment of Chemistry, The George Washington University, Washington DC 20052, United States.
Deon P NevelingDepartment of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa.
Joanna C EvansMolecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.
Valerie MizrahiMolecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.ORCID 0000-0003-4824-9115 Willem A L van OtterloDepartment of Chemistry & Polymer Science, Stellenbosch University, Stellenbosch 7600, South Africa.ORCID 0000-0002-3300-6463 Cynthia S DowdDepartment of Chemistry, The George Washington University, Washington DC 20052, United States.ORCID 0000-0001-5011-7029 Funding
Inhibitors of CoA biosynthesis as novel antitubercular and antistaphylococcal agentsR01AI136836 · NIAID · STELLENBOSCH UNIVERSITY · PI STRAUSS, ERICK · 2018 to 2022
$675kNIAID NIH HHS R01 AI136836
6 · The paper itselfAbstract
The bifunctional bacterial CoaBC is a coenzyme A (CoA) biosynthetic protein that serves as a validated bactericidal target in
Indexed as
Anti-Bacterial AgentsBacterial ProteinsEnzyme InhibitorsMycobacterium tuberculosisPeptide SynthasesProdrugsStaphylococcus aureusActivation, MetabolicMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial AgentsBacterial ProteinsEnzyme Inhibitorspantothenate synthetasePeptide SynthasesProdrugsantimicrobials, PPCSbisubstrate mimicscoenzyme Ametabolic activationprodrug
Identifiers
PMID40459851
PMCPMC12172042
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