ArticleJournal of neuro-oncology2025
A white matter-centered approach to investigate recurrence pathways in high-grade gliomas: a single-center retrospective study.
Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- White matter pathlength maps from diffusion-weighted MRI tractography for radiotherapy target planning in glioblastoma.Journal of neuro-oncology · 2026Article
- Rethinking white matter-tumor interaction: a tractography based analysis of associations between fractional anisotropy and morphometry in the IFOF and arcuate fasciculus.Journal of neuro-oncology · 2026Article
- A voxel-based quantitative framework for analyzing the spatial redistribution and directionality of recurrence in glioblastoma.Journal of neuro-oncology · 2026Article
- Free water elimination tractometry reveals local and remote white matter alterations in diffuse gliomas.Journal of neuro-oncology · 2025Article
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17 authors.
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Abstract
BACKGROUND AND
aimHigh-grade gliomas (HGGs) are aggressive primary brain tumors with inevitable recurrence. This single-center retrospective study investigates whether the anatomical proximity of HGGs to major white matter tracts influences progression and recurrence. The study explores the association between tumor location and recurrence type-local, remote, or ependymal-and whether recurrences align with adjacent white matter tracts.
methodsThe study included patients with histopathologically confirmed recurrent HGGs who underwent reoperation. Primary tumors were categorized into four anatomical subgroups using a connectivity-based framework from the HCP 1065 Atlas: Subgroup A: Long Fronto-Temporo-Parietal Network Subgroup B: Temporal Pole Network (further divided into B1, B2, and B3 based on connectivity patterns) Subgroup C: Frontal Pole Network Subgroup D: Commissural and Projection Networks (further divided into D1 and D2). Recurrences were classified via post-contrast T1-weighted MRI as local, remote, ependymal. The Tract-to-Region Connectome (T-R-C) assessed the volumetric overlap between recurrence maps and main white matter bundles.
resultsOf 41 patients, a significant correlation emerged between tumor subgroup and recurrence type (p = 0.0003). Subgroup A predominantly showed remote recurrences (68%), while B2, B3, C, and D2 had mainly local recurrences. Subgroup D1 had a predominance of ependymal recurrences (66.7%). Local and remote recurrences largely conformed to adjacent white matter distributions, with variations in timing of recurrence and survival observed across different groups.
conclusionOur analysis, focused on exploring the spatial aspects of recurrence in relation to white matter anatomy, suggests that HGG recurrence patterns are strongly influenced by anatomical location and white matter architecture. Certain anatomical areas show a predisposition toward specific recurrence patterns. Recognizing these spatial dynamics may guide more precise surgical strategies, radiotherapy targeting, and recurrence risk assessment.
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