Evidence map›Paper›PMID 40459829›Full record

ArticleDoklady. Biochemistry and biophysics2025

Antitumor Effect of Helium Ions with Energy of 320 MeV/Ion during Irradiation of Ehrlich Ascites Carcinoma Cells Ex Vivo.

V E Balakin, N S Strelnikova, O M Rozanova, E N Smirnova, T A Belyakova, A E Shemyakov

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

V E BalakinPhysical-Technical Center of Lebedev Physical Institute, Russian Academy of Sciences, Protvino, Russia.
N S StrelnikovaPhysical-Technical Center of Lebedev Physical Institute, Russian Academy of Sciences, Protvino, Russia. strelnikova.ns@lebedev.ru.
O M RozanovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
E N SmirnovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
T A BelyakovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
A E ShemyakovPhysical-Technical Center of Lebedev Physical Institute, Russian Academy of Sciences, Protvino, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regularities of tumor induction and growth were studied in mice after a single ex vivo irradiation with a helium ion beam of Ehrlich adenocarcinoma ascites cells (EAC) at doses of 10 and 20 Gy in two positions of the Bragg curve (before the peak and at the peak) in comparison with X-ray radiation at the same doses. It was shown that the frequency of induction and delay in tumor appearance depend on the dose of helium ion irradiation. The following parameters were determined: the time of a fivefold increase in the EAC volume, tumor growth inhibition, tumor growth index (TGI), and lifetime increase (LTI) in mice. A decrease in the TGI values and an increase in the LTI values occurred with increasing dose for all types of radiation. The relative biological effectiveness (RBE) value for helium ions determined by the area under the EAC growth dynamics curves reached a maximum value of 1.8 upon irradiation at the Bragg peak at a dose of 20 Gy.

Indexed as

Carcinoma, Ehrlich TumorHeliumAnimalsCell Line, TumorMaleMiceHeliumEhrlich ascites carcinomaex vivohelium ionsmicetumor growth

Identifiers

PMID40459829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.