SynthesisArchives of toxicology2025
The neurotoxic threat of micro- and nanoplastics: evidence from In Vitro and In Vivo models.
Synthesis in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Micro- and nanoplastics-induced neurotoxicity: a CNS-centered, evidence-graded adverse outcome pathway framework based on systematic weight-of-evidence assessment.Archives of toxicology · 2026Review
- Pollutant Burden in Autism Spectrum Disorder: Mechanistic Convergence, Genetic Susceptibility, and Clinical Translation.Current issues in molecular biology · 2026Review
- Micro/Nanoplastics Drive Amyloid‑β Colloidal and Oxidative Reorganization: A Real-World Contaminant Stressor.ACS omega · 2026Article
- Micro- and Nanoplastics in the Human Brain: Mechanistic Plausibility, Translational Challenges, and Links to Neurological Disease Trends.Molecular neurobiology · 2026Review
- Parental polystyrene nanoplastics exposure increases susceptibility to pathogen infection in offspring via H3K36me3-UPRCell communication and signaling : CCS · 2026Article
- Micro- and nanoplastic exposure as an emerging risk factor for depressive-like phenotypes across species: a systematic review.Frontiers in toxicology · 2026Review
- Central nervous system concentrations of nano- and microplastics and risk of amyotrophic lateral sclerosis.Brain communications · 2026Article
- Artificial intelligence and machine learning for precision prevention of cognitive decline: integrating multimodal biomarkers, lifestyle interventions, and natural medicines from prediction to clinical practice.Frontiers in aging neuroscience · 2026Review
- Polylactic acid microplastics as metabolic disruptors: Linking gut dysbiosis to systemic toxicity by disrupting microbiota-host co-metabolism.Current research in toxicology · 2026Review
- Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects.Toxics · 2025Review
- Nano- and Microplastics in the Brain: An Emerging Threat to Neural Health.Nanomaterials (Basel, Switzerland) · 2025Review
- From environment to brain: the role of microplastics in neurobehavioral disorders.Frontiers in neuroscience · 2025Review
- Nano-structured strategies in combatting neurodegeneration.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micro- and nanoplastics (MPs/NPs), ubiquitous contaminants in ecosystems and food chains, have emerged as a significant concern due to their potential neurotoxic effects on human health. Here, we conducted a systematic review of the existing literature, which included 26 studies providing evidence from cellular and animal studies on the risks posed by MPs/NPs to the nervous system. In vitro studies reveal that MPs/NPs can disrupt the integrity of the blood-brain barrier, penetrate neurons and glial cells, impair cell membrane integrity, and induce cytotoxic effects. These plastic particles trigger oxidative stress, inflammation, and mitochondrial dysfunction, alter signaling pathways, and disrupt neuronal communication, potentially leading to neurological dysfunction, cognitive deficits, and neurodegenerative disorders like Alzheimer's and Parkinson's diseases. Animal models corroborate these findings, demonstrating behavioural changes, memory impairment and neurotransmitter imbalances following exposure to MPs/NPs. Although the evidence in humans is limited, the growing body of hazard data underlines the potential risks associated with chronic exposure and accumulation of MPs/NPs in the nervous system. This highlights the urgent need for further research to elucidate the mechanisms of neurotoxicity, as well as stringent regulatory measures to restrain plastic pollution and safeguard neurological health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.