Evidence map›Paper›PMID 40459746›Full record

ArticleAnalytical and bioanalytical chemistry2025

Preparation of mitochondria-targeted gold nanoprobes and their SERS application in the detection of DON-induced apoptosis.

Zhiyi Song, Jinchi Han, Shuting Wang, Jiayu Yuan, Zhouping Wang, Xiaoyuan Ma

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Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Zhiyi SongState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Jinchi HanState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Shuting WangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Jiayu YuanState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Zhouping WangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Xiaoyuan MaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China. maxy@jiangnan.edu.cn.

Funding

Jiangsu Agriculture Science and Technology Innovation Fund CX(23)3045National Natural Science Foundation of China 32372422
6 · The paper itself

Abstract

Deoxynivalenol (DON) is a fungal toxin and commonly found in cereals. Its cytotoxicity occurs through the mitochondria-mediated apoptotic pathway. In this paper, a surface-enhanced Raman spectroscopy (SERS) method has been utilized for monitoring of biomolecules in the mitochondrial region. Gold nanostars (AuNSs) were first modified with triphenylphosphine (TPP). It could realize mitochondria targeting while serving as the SERS substrate to enhance the Raman spectra during the dynamic processes of intracellular substances. Results showed that AuNSs-TPP had good physiological stability and less cytotoxicity. DON was then used to establish the apoptosis model of HepG2 cells. SERS spectra of cells with different DON incubation times using AuNSs-TPP were monitored. The specific Raman peaks corresponded to different intracellular substances. The spectra revealed that the high-level structure of proteins in mitochondria was the first to be disrupted, followed by the disintegration of the double-helix structure of DNA and then the increase of glycogen. Besides, SERS spectra for the cells pretreated with resveratrol (Res) verified its inhibitory effect on apoptosis in HepG2 cells. This AuNSs-TPP-based SERS assay realized the in situ monitoring of DON-induced apoptosis. It has prospects for research on mycotoxin-induced cell damage in the field of food safety.

Indexed as

ApoptosisGoldMetal NanoparticlesMitochondriaSpectrum Analysis, RamanTrichothecenesHep G2 CellsHumansOrganophosphorus CompoundsdeoxynivalenolGoldOrganophosphorus CompoundsTrichothecenestriphenylphosphineApoptosisDeoxynivalenolGold nanostarsResveratrolSurface-enhanced Raman spectroscopy

Identifiers

PMID40459746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.