Evidence map›Paper›PMID 40459729›Full record

ReviewCurrent microbiology2025

Prospects of Synthetic Biology-Based Approaches in the Enhanced Production of Pyocyanin in Pseudomonas aeruginosa MCCB 117 as the Drug of Choice in Aquaculture.

Jini Jimmy, Jayesh Puthumana, Valsamma Joseph, I S Bright Singh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Principles for Rigorous Design and Application of Synthetic Microbial Communities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jini JimmyNational Centre for Aquatic Animal Health, Cochin University of Science and Technology, Cochin, Kerala, 682016, India.
Jayesh PuthumanaNational Centre for Aquatic Animal Health, Cochin University of Science and Technology, Cochin, Kerala, 682016, India.
Valsamma JosephNational Centre for Aquatic Animal Health, Cochin University of Science and Technology, Cochin, Kerala, 682016, India.
I S Bright SinghNational Centre for Aquatic Animal Health, Cochin University of Science and Technology, Cochin, Kerala, 682016, India. isbsingh@gmail.com.ORCID http://orcid.org/0000-0003-4482-2084

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyocyanin, the nitrogen-containing heterocyclic phenazine compound produced by Pseudomonas aeruginosa, has been proven to be a potential drug of choice against vibriosis in sustainable aquaculture production systems. Considering the cost of production and the fact that pyocyanin is produced in very small quantities in nature genetic improvement of bacterial strains for enhanced production of pyocyanin is a requirement. In-depth studies on the key biomolecules behind the biosynthesis of pyocyanin in P.aeruginosa has been conducted previously, however, gene level manipulations of the pyocyanin biosynthetic pathway has to be experimented enhancing the yield in P.aeruginosa. In this review, we look in to the molecular mechanism behind pyocyanin production in P. aeruginosa and an attempt has been made to investigate the growing scope of microbial synthetic biology in pyocyanin biosynthesis. In the present scenario where, synthetic biology-based tools are gaining much importance, this review throws light to building up a platform for synthetic biology-based production of pyocyanin.

Indexed as

Anti-Bacterial AgentsPseudomonas aeruginosaPyocyanineSynthetic BiologyAquacultureBiosynthetic PathwaysAnti-Bacterial AgentsPyocyanine

Identifiers

PMID40459729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.