ArticleCanadian journal of public health = Revue canadienne de sante publique2025
The effect of take-home naloxone kits on opioid-related deaths in Alberta, Canada: An ecological analysis.
Article in Canadian journal of public health = Revue canadienne de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Responding to the toxic drug crisis: Promising innovations, gaps, and calls to action.Canadian journal of public health = Revue canadienne de sante publique · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo estimate the association between publicly provided take-home naloxone kits and opioid-related deaths.
methodsWe analyzed 2732 opioid-related deaths and the distribution of 147,814 naloxone kits between January 2015 and June 2019 across five health zones in Alberta, Canada. We used a Poisson pseudo-maximum likelihood regression model with fixed effects to estimate the association between the number of kits in circulation and the number of monthly opioid-related deaths, controlling for population demographics, socio-economic indicators, other harm reduction strategies, police seizures of fentanyl and carfentanil, and an estimate of awareness.
resultsEvery 10,000 kits in circulation was associated with a 23.9% (95% confidence interval (CI), 12.6-33.7) reduction in opioid-related deaths. Marginal analysis suggests that if no kits had been distributed, Alberta would have had 3548 deaths (95% CI, 2264-4831), 816 more deaths than were recorded during this 4.5-year period. If during this time 200,000 kits were consistently in circulation, Alberta would have had an estimated 1587 deaths (95% CI, 705-2468), 1145 fewer deaths than recorded.
conclusionThis analysis provides evidence that the availability of naloxone kits is associated with a reduction in opioid-related deaths and suggests that a publicly funded program that allows the distribution of naloxone kits to all who request them reduces mortality.
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