Evidence map›Paper›PMID 40459633›Full record

ArticleCurrent microbiology2025

Carbapenem Resistant Serratia marcescens Harboring bla

Amna Kausar, Muhammad Sohail, Mohsin Khurshid, Hafiz Ghulam Murtaza Saleem

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Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Amna KausarDepartment of Medical Lab Technology, Faculty of Rehabilitation & Allied Health Sciences, Riphah International University Islamabad, Lahore, 54000, Pakistan.
Muhammad SohailDepartment of Medical Lab Technology, Faculty of Rehabilitation & Allied Health Sciences, Riphah International University Islamabad, Lahore, 54000, Pakistan. drsohailmmg@gmail.com.ORCID http://orcid.org/0000-0001-5035-5019
Mohsin KhurshidInstitute of Microbiology, Government College University Faisalabad, Faisalabad, Pakistan.
Hafiz Ghulam Murtaza SaleemDepartment of Medical Lab Technology, Faculty of Rehabilitation & Allied Health Sciences, Riphah International University Islamabad, Lahore, 54000, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of Serratia marcescens as a significant healthcare-associated pathogen is compounded by its rising carbapenem resistance resulting in a critical global health challenge. This study is the first in Pakistan to comprehensively characterize the antimicrobial resistance patterns and molecular mechanisms of S. marcescens from clinical specimens. The S. marcescens isolates were obtained from clinical specimens collected at tertiary care hospitals in Lahore and Faisalabad, Pakistan, between October 2023 and September 2024. Isolates were identified using the Vitek-2 system and MALDI-TOF mass spectrometry. The disk diffusion assays, and broth microdilution method were used for antimicrobial susceptibility testing. The antimicrobial resistance determinants were amplified by PCR followed by sanger sequencing. The study revealed concerning resistance rates among S. marcescens isolates: 78% were resistant to third-generation cephalosporins, 52% to carbapenems, and 71.6% to fluoroquinolones. However, no isolates were found to be resistant to the tigecycline. The carbapenem resistance genes were distributed among carbapenem-resistant S. marcescens (CRSM) strains as follows: bla

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsDrug Resistance, Multiple, BacterialSerratia InfectionsSerratia marcescensHumansMicrobial Sensitivity TestsPakistanAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenems

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.