Evidence map›Paper›PMID 40459533›Full record

ArticleAlimentary pharmacology & therapeutics2025

Research Communication: Breath Testing for Colorectal Cancer Detection in Patients With a Positive Fecal Immunochemical Test: A Multicentre Prospective Cross-Sectional Study With External Validation.

Milou L M van Riswijk, Kelly E van Keulen, Adriaan C I T L Tan, Ruud W M Schrauwen, Wouter H de Vos Tot Nederveen Cappel, Peter D Siersema, eNose CRC study group

2 registry-linked trialsAbstract readMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alimentary pharmacology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03346005 nacompletednot on this map

Detection of Colorectal Cancer in Patients With a Positive Fecal Immunochemical Test Using an Electronic Nose Device (AeoNoseTM)

TypeinterventionalSponsorRadboud University Medical CenterRan2017 to 2019Enrolled3,345ConditionsColorectal Cancer, Polyps of ColonArmsAeonose
NCT04357158 nacompletednot on this map

Breath analysiS as an Additional Test for ColoREctal cancEr screeNing to rEduce the Number of unnecessaRy Colonoscopies

TypeinterventionalSponsorRadboud University Medical CenterRan2020 to 2022Enrolled750ConditionsColorectal Cancer, Polyp of Colon, Colorectal NeoplasmsArmsAeonoseTM
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Milou L M van RiswijkDepartment of Gastroenterology and Hepatology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-0589-685X
Kelly E van KeulenDepartment of Gastroenterology and Hepatology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Adriaan C I T L TanDept. of Gastroenterology and Hepatology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
Ruud W M SchrauwenDept. of Gastroenterology and Hepatology, Bernhoven, Uden, the Netherlands.
Wouter H de Vos Tot Nederveen CappelDept. of Gastroenterology and Hepatology, Isala Hospital, Zwolle, the Netherlands.
Peter D SiersemaDepartment of Gastroenterology and Hepatology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
eNose CRC study group

Funding

European Regional Development Fund R0004988Maag Lever Darm Stichting project I 17-12
6 · The paper itself

Abstract

Colorectal cancer (CRC) screening using fecal immunochemical tests (FIT) is suboptimal. This multicentre study evaluated an electronic nose (e-nose) for CRC detection in FIT-positive patients, along with reproducibility and external validation. Among 3469 participants (40.1% female, median age 64.3y), CRC was diagnosed in 5.0%; 25.1% had a normal colonoscopy. The e-nose showed poor diagnostic performance (AUC 0.542; sensitivity 39.5%; specificity 68.3%) and low reproducibility (ICC 0.22). Despite high patient acceptability (95.3% willingness-to-repeat), these findings suggest e-nose technology is not yet ready for clinical implementation. Further research is needed to standardise and validate e-nose devices before supplementing current screening methods. Clinicaltrials.gov Identifier NCT03346005 and NCT04357158.

Indexed as

Colorectal NeoplasmsEarly Detection of CancerElectronic NoseFecesAgedBreath TestsCross-Sectional StudiesFemaleHumansMaleMiddle AgedOccult BloodProspective StudiesReproducibility of ResultsSensitivity and Specificitycolonoscopycolorectal cancerelectronic nosescreeningsurveillancevolatile organic compounds

Identifiers

PMID40459533
PMCPMC12203142

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.