ArticleTranslational vision science & technology2025
Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study.
Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Inter-Eye Differences of the Circumpapillary Microvasculature in Primary Open-Angle Glaucoma.Translational vision science & technology · 2026Article
- Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.Investigative ophthalmology & visual science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Purpose: To explore interocular asymmetry in retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT), assess factors that predict this asymmetry, and quantify the 95% central range for OCT-defined average cup-disc ratio (CDR). Methods: Participants from the Framingham Heart Study were included. Interocular differences in OCT parameters were calculated by subtracting left eye values from the right eye. To quantify the range for interocular differences, the percentile distributions were described, with normal ranges established as 2.5th to 97.5th percentiles. Multivariable linear regression models were employed to explore predictors of interocular differences in RNFL thickness. Results: In total, 522 participants were studied with a mean (standard deviation [SD]) age of 74.5 (6.9) years, and most were female (59.4%) and white (88.3%). The mean (SD) peripapillary RNFL thickness was 88.1 (9.7) in the right eye and 87.7 (9.7) in the left eye, with a nonstatistically significant difference (mean [SD], 0.4 [6.1]; P = 0.18). The 2.5th and 97.5th percentiles for the interocular difference in average RNFL were -12.7 µm and 12.7 µm, while that of average CDR was -0.19 and 0.21, respectively. In multivariable models, only differences in rim area (β = 8.06/mm2; P < 0.001) and differences in signal strength (β = 1.37/unit; P < 0.001) were significantly and positively associated with interocular differences in average RNFL thickness. Conclusions: The 95% limits for average RNFL and CDR were within 12.7 microns and 0.2 units, respectively, between eyes. Translational Relevance: Comparing OCT RNFL of both eyes may aid in detecting early cases of unilateral/asymmetric glaucoma or other optic nerve-related pathology when used in conjunction with other clinically or biologically relevant findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.