ArticleInvestigative ophthalmology & visual science2025
The Efficiency and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking in Rabbits.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Immune inflammatory targets and anti-inflammatory therapy in dry eye disease.International ophthalmology · 2026Review
- γδ T Cell-Mediated Neuroimmune Interactions in Skin Inflammation and Allergy.Clinical reviews in allergy & immunology · 2026Review
- In Vivo Evaluation of Efficacy and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking Over Time in Young Rabbits.Translational vision science & technology · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to evaluate the efficacy and safety of accelerated scleral collagen cross-linking (SXL) with supplemental oxygen. Methods: The rabbit scleral tissues were randomly divided into seven different SXL protocols, including traditional (T)-SXL (3 mW/cm2 for 30 minutes, 3*30) and accelerated (A)-SXL (30 mW/cm2 for 3, 5, or 8 minutes, respectively, with or without supplemental oxygen). The control group received no ultraviolet-A (UVA) radiation. The tangent modulus of scleral strip was determined by uniaxial tensile test. The protocol with better mechanical property and shorter cross-linking time in vitro was selected for immediate safety assessment using electroretinogram (ERG) in vivo, hematoxylin and eosin (H&E) staining and TUNEL assay in vitro. Results: The tangent modulus was significantly greater in all SXL groups compared to the control group. The equatorial sclera showed a larger stiffening effect than the posterior. In the equatorial sclera, extending the irradiation time in normoxic A-SXL can result in a further enhancement of the stiffening effect. The tangent modulus was enhanced by 92% in the hyperoxic A-SXL group (30*3) compared with the normoxic A-SXL (30*3) group, and achieved the same mechanical performance as the T-SXL group. The oxygen supplementation did not play a role in further improving he stiffening effect at the posterior sclera. The ERG and H&E staining indicated no abnormalities in the sclera and retina. Apoptosis was only observed in the outer layer of the sclera in the A-SXL groups. Conclusions: A-SXL protocol of 30 mW/cm2 can improve the mechanical properties of the sclera. In particular, the protocol of 30 mW/cm2 for 3 minutes with supplemental oxygen showed excellent cross-linking efficacy with shorter surgical time and was relatively safe.
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