ReviewSmall (Weinheim an der Bergstrasse, Germany)2025
Clustering of Membrane Receptors: Insights from DNA Origami-Based Approaches.
Review in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Multiparatopic antibodies overcome tyrosine kinase inhibitor resistance by inducing lysosomal degradation of EGFR mutants.Oncogene · 2026Article
- From Blueprint to Breakthrough: How Far Can We Fold DNA Origami for Nano-Enabled Technologies?JACS Au · 2026Review
- The Application of Micro/Nanorobots in Cancer Therapy.Micromachines · 2026Review
- Review
- Functionalizing Nucleic Acids: Synthesis and Purification Strategies for Bioconjugates as Biomaterials.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Characterization of Non-Specific Electrostatic Interactions of Cationic Peptides with DNA Origami and Their Functional Consequences.Small methods · 2026Article
- Multivalent DNA Origami Enables Single-Molecule Dissection of Integrin αvβ6-Receptor Tyrosine Kinase Crosstalk in Cancer Biology.ACS nano · 2025Article
- Clustering of Membrane Receptors: Insights from DNA Origami-Based Approaches.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell signaling enables cells to interpret and respond to their environment, relying on receptor interactions that regulate key biological functions. While receptor-ligand affinity is crucial, receptor clustering plays a central role in modulating signaling efficiency, influenced by factors such as membrane diffusivity, lipid organization, and receptor-receptor interactions. While advances in imaging have long contributed to a better understanding of this fundamental biological mechanism, recent breakthroughs in nanotechnology, particularly the use of DNA origami nanostructures (DONs), now enable the precise manipulation of receptor-ligand interactions. This opens up unprecedented insights into the dynamics of signal transduction at the nanoscale and holds promising potential for innovative therapeutic applications. The examples presented in this article, based on various classes of receptors, illustrate how these groundbreaking developments can not only lead to a more detailed mechanistic understanding, but also pave the way for the development of new molecular therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.