Observational studyJournal of paediatrics and child health2025
Diaphragmatic Ultrasonography in Preterm Newborns With Respiratory Distress Syndrome on Invasive Mechanical Ventilation: An Observational Study.
Observational study in Journal of paediatrics and child health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Evolution of diaphragmatic thickness and function in preterm infants on non-invasive neurally adjusted ventilatory assist.European journal of pediatrics · 2026Observational
- Agreement of Diaphragmatic Excursion Between Anterior Subcostal and Posterior Subcostal Ultrasonography in Premature Neonates.Pediatric pulmonology · 2026Article
- Seeing readiness: a pilot diagnostic accuracy study integrating diaphragm and lung ultrasound to predict extubation outcomes in the NICU.European journal of pediatrics · 2026Article
- Diaphragmatic Ultrasonography in Preterm Newborns With Respiratory Distress Syndrome on Invasive Mechanical Ventilation: An Observational Study.Journal of paediatrics and child health · 2025Observational
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn preterm newborns, Respiratory Distress Syndrome (RDS) is one of the leading causes of mortality. Treatment often requires invasive mechanical ventilation (IMV), which can cause diaphragmatic dysfunction. Ultrasonography is a promising tool for assessing diaphragmatic function in neonates. This study analyses changes in the diaphragm muscle of preterm newborns with RDS undergoing IMV.
methodsA longitudinal study was conducted with preterm newborns diagnosed with RDS and subjected to IMV. Clinical data were collected, and ultrasonographic evaluations of diaphragm thickness and diaphragmatic thickening fraction (DTF) were performed at two time points: within the first 48 h of life and up to 48 h after extubation.
resultsThere was a significant reduction in diaphragmatic thickness (p < 0.0001), DTF index (p = 0.01), and diaphragmatic excursion (p = 0.02) during the intubation period. A moderate correlation was observed between DTF and IMV duration (R = 0.62), hospitalisation time (R = 0.52), and the risk of reintubation (R = 0.55). A moderate correlation was also identified between IMV duration and hospitalisation time (R = 0.64) and between diaphragmatic thickness and gestational age (R = 0.58). However, the correlation between DTF and gestational age was weak (R = 0.48).
conclusionIMV leads to diaphragmatic deterioration with increased muscle atrophy in preterm newborns with respiratory distress syndrome.
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