Evidence map›Paper›PMID 40459076›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2025

Genetic Analysis of the X Chromosome Associates Loci with Progression of Parkinson's Disease.

Yu Liao, Hao Wu, Junhao Wang, Jean-Christophe Corvol, Jodi Maple-Grødem, Meghan C Campbell, Alexis Elbaz, Alexis Brice, Michael A Schwarzschild, Pille Taba and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yu LiaoShenzhen Key Laboratory of Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China.
Hao WuShenzhen Key Laboratory of Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China.
Junhao WangShenzhen Key Laboratory of Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China.
Jean-Christophe CorvolSorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Hôpital Pitié-Salpêtrière, Paris, France.
Jodi Maple-GrødemThe Centre for Movement Disorders, Centre for Brain Health, Stavanger University Hospital, Stavanger, Norway.ORCID https://orcid.org/0000-0001-7142-0078
Meghan C CampbellDepartment of Neurology and Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Alexis ElbazUniversité Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Villejuif, France.ORCID https://orcid.org/0000-0001-9724-5490
Alexis BriceSorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Hôpital Pitié-Salpêtrière, Paris, France.
Michael A SchwarzschildDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Pille TabaDepartment of Neurology and Neurosurgery, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Sulev KõksCentre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, Australia.
Thomas G BeachBanner Sun Health Research Institute, Sun City, Arizona, USA.ORCID https://orcid.org/0000-0003-3296-6128
Guido AlvesThe Centre for Movement Disorders, Centre for Brain Health, Stavanger University Hospital, Stavanger, Norway.
Ole-Bjørn TysnesDepartment of Neurology, Haukeland University Hospital, Bergen, Norway.
Joel S PerlmutterDepartment of Neurology and Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Baijayanta MaitiDepartment of Neurology and Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-2583-4947
Jacobus J van HiltenDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Roger A BarkerJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Caroline H Williams-GrayJohn Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-2648-9743
Clemens R ScherzerStephen & Denise Adams Center for Parkinson's Disease Research, Yale School of Medicine, New Haven, Connecticut, USA.
Ganqiang LiuShenzhen Key Laboratory of Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China.ORCID https://orcid.org/0000-0002-1921-9542
International Genetics of Parkinson Disease Progression Consortium

Funding

Genome-Wide Prediction of Dementia in Parkinson's DiseaseR01NS115144 · NINDS · YALE UNIVERSITY · PI SCHERZER, CLEMENS R · 2019 to 2025
$4.4M
Cerebellar cholinergic connections as a biomarker of dementia and gait impairment in Parkinson diseaseK23NS125107 · NINDS · WASHINGTON UNIVERSITY · PI Baijayanta Maiti · 2022 to 2026
$916k
National Institutes of Health grants NINDS/NIA R01NS115144National Natural Science Foundation of China 32270701National Natural Science Foundation of China 32470708NINDS NIH HHS K23 NS125107NINDS NIH HHS R01 NS115144Shenzhen Fundamental Research Program JCYJ20240813151132042Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases ZDSYS20220606100803007The Science and Technology Planning Project of Guangdong Province 2023B1212060018Young Talent Recruitment Project of Guangdong 2019QN01Y139
6 · The paper itself

Abstract

backgroundGenetic variants on the X chromosome have been linked to susceptibility for Parkinson's disease (PD), but their roles in disease progression remain unclear.

objectivesThis study investigated associations between X chromosome variants and longitudinal cognitive decline or motor impairment in patients with PD.

methodsWe conducted combined (male + female) and stratified X-chromosome-wide survival studies (XWSS) in 4467 patients with PD with 33,406 longitudinal visits. Cognitive decline was defined as global cognitive impairment (GCI, Mini Mental State Exam score ≤25), whereas motor impairment was evaluated by Hoehn and Yahr stage 3 (HY3). Expression quantitative trait locus (eQTL) and genetic colocalization analyses were systematically performed.

resultsWe identified 40 common variants in the X-chromosome-wide screen associated with longitudinal progression of PD with P-value <9.27 × 10

conclusionsOur XWSS identified novel genetic progression-associated loci on the X chromosome for PD, providing new insights into the X chromosome-linked genetic underpinnings of PD. © 2025 International Parkinson and Movement Disorder Society.

Indexed as

Chromosomes, Human, XCognitive DysfunctionParkinson DiseaseAgedDisease ProgressionFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LocieQTLParkinson's diseaseprogressionX‐chromosome‐wide survival study

Identifiers

PMID40459076
PMCPMC12353966

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.