Evidence map›Paper›PMID 40459069›Full record

ReviewThe journal of physical chemistry letters2025

Amphiphilic Copolymers and Their Role in the Study of Membrane Proteins.

Gestél C Kuyler, Elaine Barnard, Randy D Cunningham, Sinothando Sibariboyi, Luke White, Ilanie Wessels, Michael-Phillip Smith, Bennie Motloung, Bert Klumperman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of physical chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gestél C KuylerDepartment of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.ORCID 0000-0003-2396-151X
Elaine BarnardDepartment of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.
Randy D CunninghamDepartment of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.
Sinothando SibariboyiDepartment of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.ORCID 0000-0003-1935-5728
Luke WhiteDepartment of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.
Ilanie WesselsDepartment of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.
Michael-Phillip SmithDepartment of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.ORCID 0000-0003-1166-2520
Bennie MotloungDepartment of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.ORCID 0000-0002-8041-0725
Bert KlumpermanDepartment of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.ORCID 0000-0003-1561-274X

Funding

Wellcome Trust
6 · The paper itself

Abstract

Amphiphilic copolymers have revolutionized the study of membrane proteins (MPs), where MPs are known to be critical targets in pharmaceutical development due to their roles in various physiological processes. Traditionally, MP extraction has relied on detergents, which often compromise the protein integrity. Advancements over the past 15 years include the use of poly(styrene-

Indexed as

MaleatesMembrane ProteinsPolymersPolystyrenesMaleatesmaleic acidMembrane ProteinsPolymersPolystyrenesstyrene-maleic acid polymer

Identifiers

PMID40459069
PMCPMC12169657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.