ArticleCardiology journal2025
Aspiration thrombectomy compared to catheter directed thrombolysis in pulmonary embolism: Outcomes from a tertiary referral center.
Article in Cardiology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Comparative Outcomes of Ultrasound-Assisted Thrombolysis and Mechanical Thrombectomy in Intermediate-High-Risk Pulmonary Embolism.Journal of clinical medicine · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrompt treatment of pulmonary embolism (PE) prevents morbidity and mortality. The aim of the present study was to evaluate and compare the effectiveness of two FDA-approved catheter-based therapies (CBT) for acute PE: ultrasound-assisted catheter-directed thrombolysis EKOS (EKOS Corporation, Bothell, WA) and Penumbra Indigo aspiration thrombectomy (Penumbra Inc., Alameda, CA, USA).
methodsPatients with submassive and massive PE who underwent CBT between 09/2014 and 08/2022 at our institution were identified. Primary efficacy outcome was change in the echocardiographic RV/LV diameter ratio within 48 to 72h of the procedure.
resultsA total of 189 patients underwent EKOS (n=119) or Penumbra (n = 70) for submassive (n = 175) and massive (n = 14) PE. The RV/LV ratio showed improvement post intervention, with 21.2% decrease in the EKOS group (EG) and 35.6% in the Penumbra group (PG). PG group had a greater reduction in RV/LV (median change 0.396 (IQR, 0.347) vs. 0.207 (IQR, 0.306), p < 0.001). The rate of complications and in-hospital mortality were similar (15.1% in EG and 10% in PG and 2.5% in EG, 4.3% in PG, p = 0.672; respectively). Subgroup analysis comparing responders, defined as patients with a post-intervention echocardiographic RV/LV ratio < 0.9, and non-responders showed a lower rate of chronic lung disease, (4.3% vs. 19.0%, p = 0.015).
conclusionsBoth CBT options are promising for treating acute submassive or massive PE, with efficacy outcomes favoring aspiration thrombectomy. Presence of chronic lung disease was associated with lower response to CBT in terms of reversal of RV dysfunction. Longer follow-up and randomized controlled trials are needed for definitive conclusions.
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