ArticleeLife2025
The role of GABA in semantic memory and its neuroplasticity.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Transcranial focused ultrasound stimulation enhances semantic memory by modulating brain morphology, neurochemistry and neural dynamics.Nature communications · 2026Article
- The Tip-of-the-Tongue Phenomenon: Cognitive, Neural, and Neurochemical Perspectives.Biomedicines · 2026Review
- Study on the cognitive effects of eye movement desensitization and reprocessing: proposed active mechanisms.Frontiers in computational neuroscience · 2026Article
- Transcutaneous vagus nerve stimulation reduces total striatal GABA+ content, increases DLPFC Glu content, and facilitates early-phase motor learning.Frontiers in human neuroscience · 2026Article
- Prefrontal and Cerebellar Contributions to Semantic Memory Retrieval.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Article
- Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer's disease therapy.Frontiers in pharmacology · 2025Review
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Authors and funding
3 authors.
Funding
Abstract
A fundamental challenge in neuroscience is understanding neural functioning and plasticity of the brain. The anterior temporal lobe (ATL) is a hub for semantic memory, which generates coherent conceptual representations. GABAergic inhibition plays a crucial role in shaping human cognition and plasticity, but it is unclear how this inhibition relates to human semantic memory and its plasticity. Here, we employed a combination of continuous theta burst stimulation (cTBS), MR spectroscopy and fMRI to investigate the role of GABA in semantic memory and its neuroplasticity. We found that inhibitory cTBS increased GABA concentrations in the ATL and reduced blood-oxygen level-dependent (BOLD) activation during semantic tasks. Crucially, changes in GABA were tightly linked to changes in regional activity, suggesting that GABA mediates cTBS-induced plasticity. Individuals with better semantic performance exhibited selective activity in the ATL, attributable to higher GABA levels, which can sharpen distributed semantic representations. Our results revealed a non-linear, inverted-U-shape relationship between GABA levels in the ATL and semantic performance, thus offering an explanation for the individual differences in semantic memory function and neuromodulation outcomes. These findings offer a neurochemical explanation for individual variability in neuromodulation and provide insights for developing targeted interventions for semantic impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.