ArticleCNS neuroscience & therapeutics2025
Functional MRI Analysis of Brain Activity in Rats With Diabetic Bladder Dysfunction.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsThis study aimed to investigate brain activity using functional magnetic resonance imaging (fMRI) in rats with 12-week diabetic bladder dysfunction (DBD). Furthermore, as prior research has suggested that NLX-112, a 5-HT
methodsMale Sprague-Dawley rats were anesthetized with urethane and underwent cystometry alongside 9.4-Tesla fMRI evaluations. Resting-state fMRI was performed on empty bladders to compare baseline brain activity between groups. Gradient echo-planar imaging was utilized to assess brain activation during micturition relative to relaxation, and a group analysis was conducted.
resultsfMRI data from 12 diabetes mellitus (DM) rats and 12 normal control (NC) rats were analyzed. DM rats exhibited a significant reduction in the amplitude of low-frequency fluctuation (ALFF) in the basal forebrain and cerebral cortex, a measurement of activity in brain networks. During micturition, DM rats showed increased activation in the thalamus, primary motor cortex, periaqueductal gray (PAG) and other regions. NLX-112 administration did not significantly alter brain activity in DM rats.
conclusionDBD rats exhibit heightened thalamic and PAG activity during micturition, potentially due to enlarged bladder capacity, with cortical activity serving as a compensatory mechanism. These findings highlight potential neural targets for DBD treatment.
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