Evidence map›Paper›PMID 40458876›Full record

ArticleStroke2025

SEW2871 Attenuates Blood-Brain Barrier Damage and Neuropathological Outcomes Related to Cerebral Small Vessel Disease.

Bushra Shal, Michael Griego, Yirong Yang, Carlos Perez, Laurel Sillerud, Haoran Deng, Halima Akter, Joanna McChriston, Haojie Chen, Sean Maez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bushra ShalDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.ORCID 0000-0003-4696-8781
Michael GriegoDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.
Yirong YangCollege of Pharmacy (Yirong Yang), University of New Mexico Health Science Center, Albuquerque.
Carlos PerezDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.
Laurel SillerudDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.ORCID 0000-0002-5115-4339
Haoran DengDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.
Halima AkterDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.
Joanna McChristonDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.
Haojie ChenDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.ORCID 0009-0009-6614-8204
Sean MaezDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.
Yi YangDepartment of Neurology (B.S., M.G., C.P., L.S., H.D., H.A., J.M.C., H.C., S.M., Yi Yang), University of New Mexico Health Science Center, Albuquerque.ORCID 0000-0003-1493-2952

Funding

Sphingosine 1 phosphate signaling in cerebral small vessel diseaseRF1NS110724 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI YANG, YI · 2020 to 2020
$2.6M
NINDS NIH HHS RF1 NS110724
6 · The paper itself

Abstract

backgroundBlood-brain barrier (BBB) dysfunction contributes to the pathogenesis of cerebral small vessel disease. This study assessed SEW2871, a selective agonist of sphingosine-1-phosphate receptor 1, as a potential novel therapy for small vessel disease by targeting BBB damage using a rat model of small vessel disease.

methodsTwelve-week male and female spontaneously hypertensive rat stroke-prones were subjected to unilateral carotid artery occlusion (UCAO) and Japanese permissive diet (JPD). Three doses of SEW2871 (0.5, 1.0, and 5.0 mg/kg, delivered every other day up to 5 weeks) were tested. Dynamic body weight, oxygen saturation, and SEW2871 plasma concentration were evaluated. BBB permeability, white matter lesions and gray matter lesions, and cerebral blood flow (CBF) were assessed with preclinical magnetic resonance imaging at 2 and 5 weeks after UCAO/JPD onset. Cognitive outcomes were evaluated using Morris Water Maze during week 5 of UCAO/JPD.

resultsWe found that SEW2871 delayed the occurrence of UCAO/JPD-induced chronic hypoxic hypoperfusion in the spontaneously hypertensive rat stroke-prones. Magnetic resonance imaging showed increased BBB permeability, white matter lesions and gray matter lesions, and decreased CBF at 2 and 5 weeks after UCAO/JPD onset. T

conclusionsLong-term treatment with SEW2871 mitigated BBB leakage and brain injury, improved CBF and cognitive impairment in the spontaneously hypertensive rat stroke-prone model of small vessel disease. SEW2871 is effective at all doses, while 1.0 mg/kg dose demonstrated exceptional protection against the neuropathological cascades associated with small vessel disease.

Indexed as

Blood-Brain BarrierCerebral Small Vessel DiseasesOxadiazolesAnimalsCerebrovascular CirculationDisease Models, AnimalFemaleMaleRatsRats, Inbred SHRThiophenesOxadiazolesSEW2871Thiophenesblood-brain barriercerebral small vessel diseasegray matterhypoxic brain damagemagnetic resonance imagingphingosine-1-phosphate receptor 1white matter

Identifiers

PMID40458876
PMCPMC12303741

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.