SynthesisFrontiers in pharmacology2025
The efficacy and safety of Tisotumab vedotin in the treatment of recurrent/metastatic cervical cancer: a systematic review and meta-analysis of single-arm studies.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- A tri-scale in silico framework integrating pharmacovigilance and mechanistic modeling suggests tepotinib-associated acute kidney injury risk.Renal failure · 2026Article
- Targeted Anti-TF Antibody-Drug Conjugates in Advanced Cervical Cancer-Tisotumab Vedotin-Systematic Review.Cancers · 2026Review
- Drug-induced adverse events in modern pharmacotherapy: mechanisms, clinical manifestations, and implications for risk assessment and management.Frontiers in pharmacology · 2026Review
- Cardiotoxicity associated with anticancer therapies for gynecological tumors.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study was conducted to evaluate the efficacy and safety of Tisotumab Vedotin (TV) in the treatment of recurrent/metastatic cervical cancer (r/m CC) through a systematic review and meta-analysis. Methods: The clinical studies on the monotherapy of TV for r/m CC were retrieved comprehensively from some databases, including PubMed, Embase, and Cochrane Library. The inclusion criteria encompassed observational studies and randomized controlled trials. Data analysis was performed using STATA 15.0. Besides, the median overall survival (OS), median progression-free survival (PFS), disease control rate (DCR), objective response rate (ORR), and the incidence of adverse events (AEs) and AEs at Grades 3-5 were calculated. Results: A total of 5 articles (covering 7 studies and 527 patients) were included in this study. The meta-analysis results revealed that the median OS, median PFS, ORR, and DCR were 11.83 months, 4.22 months, 29.9%, and 75.1%, respectively, for patients treated with TV. The incidence of AEs was 99.1%, and AEs at Grades 3-5 were reported in 61.7% of patients. Conclusion: TV demonstrates significant efficacy as a second-line or third-line therapy for r/m CC, making it a promising therapeutic option. Nevertheless, large-scale randomized controlled trials are needed to validate these findings and optimize clinical application strategies. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024577046, identifier CRD42024577046.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.