Evidence map›Paper›PMID 40458789›Full record

ArticleFrontiers in pharmacology2025

Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

Eyuel Kassa, Mastewal Birhan, Mulugeta Ayalew, Aschalew Gelaw, Abdulkader Mohamedsaid Gidey, Degalem Tilahun Worku, Awole Mekonen, Ermias Teklehaimanot, Assefa Asnakew, Alazar Amare and 1 more

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Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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11 authors.

Eyuel KassaDepartment of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia.
Mastewal BirhanCollege of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia.
Mulugeta AyalewUnit of Pediatric Hematology Oncology, Department of Pediatrics and Child Health, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Aschalew GelawDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Abdulkader Mohamedsaid GideyUnit of Pediatric Hematology Oncology, Department of Pediatrics and Child Health, School of Medicine, College of Medicine and Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Degalem Tilahun WorkuUnit of Pediatric Hematology Oncology, Department of Pediatrics and Child Health, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Awole MekonenDepartment of pathology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Ermias TeklehaimanotDepartment of Pharmacy, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.
Assefa AsnakewUnit of Molecular Biology and Bioinformatics, Institute of Biotechnology, Addis Ababa University, Addis Ababa, Ethiopia.
Alazar AmareMedical Laboratory Department, Dilla University College of Medicine and Health Sciences, Dilla, Ethiopia.
Nega Berhane TessemmaDepartment of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Knowledge, attitudes, and practices (KAP) regarding the use of thiopurine chemotherapeutic drugs in the treatment of acute lymphoblastic leukemia (ALL) are critical for healthcare professionals. Thiopurines are associated with varying levels of toxicity, including myelosuppression, hepatotoxicity, and gastrointestinal intolerance. Approximately 20% of ALL patients discontinue thiopurine therapy due to toxicity and other adverse events. This study aims to assess the KAP of healthcare providers (HCPs) concerning thiopurine drugs used in the treatment of ALL in hospital wards in Northwestern Ethiopia. Methods: A hospital-based cross-sectional study was conducted among 161 HCPs at the University of Gondar Comprehensive Specialized Hospital from June 1, 2023, to August 30, 2023. Data were collected using a self-administered questionnaire. The collected data were coded, entered and analyzed using SPSS version 25. Associations between categorical variables were assessed using cross tabulation, and both crude and adjusted odds ratios were calculated with a 95% confidence interval. Variables with Results: A total of 161 HCPs participated in the study, comprising 69 (42.9%) females and 92 (57.1%) males. The majority of participants were nurses 105 (65%), followed by physicians 20 (12.4%), pharmacists 19 (11.8%), midwives 10 (6.2%), and health officers 7 (4.3%). More than half of the participants demonstrated inadequate knowledge 94 (58.4%), negative attitudes 82 (50.9%), and poor practices 90 (55.9%) regarding the use of thiopurine drugs for the treatment of ALL. Approximately 50 (31.1%) participants understood the term "thiopurine drugs," while 89 (55.3%) were aware of their adverse drug reactions. However, the majority 136 (84.5%) had not received training on how to report adverse drug reactions. Conclusion: The majority of healthcare professionals demonstrated negative attitudes, inadequate knowledge, and poor practices concerning the reporting of adverse drug reactions associated with thiopurine drugs.

Indexed as

acute lymphoblastic leukemiaadverse drug reactionsattitudeknowledgepracticethiopurine drugsthiopurine methyltransferase gene

Identifiers

PMID40458789
PMCPMC12127812

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