ArticleFrontiers in psychiatry2025
First person state/psychological imagery modulates the orbital frontal gyrus and the putamen in individuals with depression.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Patients with depression appear to imagine scenes preferentially from a 3rd person perspective as if they were observers. Methods: By using functional magnetic resonance imaging we asked patients with major depressive disorder (19, MDD) and healthy controls (19, HC) to imagine 1st person perspective state/psychological (vs. action) scenes. Results: We found that the left superior frontal gyrus (orbital part) and the right putamen were differentially activated by the state/psychological (vs. action) imagery (vs. letter detection) in MDD individuals vs. HC. Discussion: We suggest that imagery for state/psychological events increased activation in areas involved in self-related processing and personal perspective changes.
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