Clinical characteristics and treatment of unilateral allergic fungal rhinosinusitis: a retrospective case series and literature review.

Xiaodong Chen, Jiawei Chen, Jian Wang, Min Xu, Tao Xue, Dingjun Zha, Fuquan Chen

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Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Xiaodong Chen *Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China.

Jiawei Chen *Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China.

Jian WangDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China.

Min XuDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China.

Tao XueDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China.

Dingjun ZhaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China.

Fuquan ChenDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To retrospectively summarize the clinical manifestations, pathological characteristics, and efficacy of unilateral allergic fungal rhinosinusitis (AFRS), we analyzed the clinical data of 23 patients diagnosed with unilateral AFRS in a teaching hospital setting. All the patients showed positive reaction for fungal allergens via the skin prick test or serum-specific IgE test. CT scan showed lesions of the sinuses were unilateral. The average postoperative follow-up time was 72 months. Among the cases, 20 cases were cured, and 3 cases were improved. The VAS score decreased from 8.5 preoperatively to 1.1 postoperatively. The eosinophilic mucin, typical CT findings, and fungal-specific type I hypersensitivity are the three clinical features of AFRS. Endoscopic sinus surgery and oral glucocorticoids are effective treatments for AFRS.

Indexed as

AFRSendoscopic sinus surgeryfungal allergynasal polypsrhinosinusitis

Identifiers

PMID40458753

DOI10.3389/falgy.2025.1521574

PMCPMC12127287

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.