Evidence map›Paper›PMID 40458674›Full record

ArticleJournal of extracellular biology2025

Proteomics of Urinary Extracellular Vesicles Highlight the Involvement of Vitronectin and the Fibrinolytic and TNF Pathways as Mechanisms Underlying Renal Fibrosis in Kidney Transplant Patients.

Marta Clos-Sansalvador, Sergio G Garcia, Paula Rodríguez-Martínez, Marta Sanroque-Muñoz, Miriam Font-Morón, Cristina Grange, Benedetta Bussolati, Marcella Franquesa, Javier Juega, Francesc E Borràs

Abstract read
In one paragraph

Article in Journal of extracellular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marta Clos-SansalvadorREMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department, University Hospital Germans Trias i Pujol (HUGTiP), Can Ruti Campus Badalona (Barcelona) Catalonia Spain.
Sergio G GarciaREMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department, University Hospital Germans Trias i Pujol (HUGTiP), Can Ruti Campus Badalona (Barcelona) Catalonia Spain.
Paula Rodríguez-MartínezDepartment of Pathology University Hospital Germans Trias i Pujol Badalona (Barcelona) Spain.
Marta Sanroque-MuñozREMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department, University Hospital Germans Trias i Pujol (HUGTiP), Can Ruti Campus Badalona (Barcelona) Catalonia Spain.
Miriam Font-MorónREMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department, University Hospital Germans Trias i Pujol (HUGTiP), Can Ruti Campus Badalona (Barcelona) Catalonia Spain.
Cristina GrangeUniversity of Turin: Universita degli Studi di Torino Turin Italy.
Benedetta BussolatiUniversity of Turin: Universita degli Studi di Torino Turin Italy.ORCID https://orcid.org/0000-0002-3663-5134
Marcella FranquesaREMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department, University Hospital Germans Trias i Pujol (HUGTiP), Can Ruti Campus Badalona (Barcelona) Catalonia Spain.
Javier JuegaREMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department, University Hospital Germans Trias i Pujol (HUGTiP), Can Ruti Campus Badalona (Barcelona) Catalonia Spain.
Francesc E BorràsREMAR-IGTP Group Germans Trias i Pujol Research Institute (IGTP) & Nephrology Department, University Hospital Germans Trias i Pujol (HUGTiP), Can Ruti Campus Badalona (Barcelona) Catalonia Spain.ORCID https://orcid.org/0000-0003-4038-1912

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitronectin (VTN) is a potential non-invasive biomarker for renal fibrosis, originally described in urinary extracellular vesicles (uEV) from kidney transplant patients (KTx). However, VTN's specific role in renal fibrosis is unclear, as it is involved in various physiological processes. This study aims to identify other uEV-associated proteins linked to renal fibrosis to clarify which pathways involve VTN. uEV were isolated from 33 KTx patients and five healthy controls. uEV proteins were analysed using proximity extension assay (PEA), and data were normalized and compared using Welch's two-sided

Indexed as

fibrinolysisproximity extension assayrenal fibrosisTNFurinary extracellular vesiclesvitronectin

Identifiers

PMID40458674
PMCPMC12127770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.