Evidence map›Paper›PMID 40458672›Full record

ArticleJournal of extracellular biology2025

Enhanced Anti-Tumour Efficacy of iRGD-Modified Cell-Bound Membrane Vesicles (iRGD-CBMVs) as a Novel Drug Carrier.

Haonan Zhao, Zhendong Huang, Qinghua Sheng, Wenxiang Shao, Min Zeng, Kun Wang, Yang Zhang, Ying Qin, Zhihao Xiong, Lizhen Chen and 8 more

Abstract read
In one paragraph

Article in Journal of extracellular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Haonan ZhaoInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Zhendong HuangInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Qinghua ShengInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Wenxiang ShaoSchool of Chinese Medicine & Life Science Jiangxi University of Chinese Medicine Nanchang Jiangxi China.
Min ZengInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Kun WangInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Yang ZhangInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Ying QinInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Zhihao XiongInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Lizhen ChenInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Huaying WangInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Tong RongInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Zhitao QiuSchool of Life Science Nanchang University Nanchang Jiangxi China.
Hongda ZhuangInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Zhiwen WuInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Yuan ZhangInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.
Wendiao ZhangThe First Affiliated Hospital, Multi-Omics Research Center for Brain Disorders, Clinical Research Center for Immune-Related Encephalopathy of Hunan Province, Department of Neurology, Hengyang Medical School University of South China Hengyang Hunan China.ORCID https://orcid.org/0000-0002-3510-8383
Yong ChenInstitute for Advanced Study Nanchang University Nanchang Jiangxi China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer continues to be the foremost cause of mortality in humans. Persistent challenges in cancer treatment include inadequate drug targeting, severe toxicological side effects and uncontrolled drug distribution. The bioinspired membrane vesicle drug delivery systems have been emerging as promising therapeutic strategies. This study characterises unique cell-bound membrane vesicles (CBMVs), which are impervious to standard cleaning agents and effectively loaded with doxorubicin (DOX). For the first time, we used iRGD peptide to modify the CBMVs to enhance the CBMVs' targeting capabilities for cancer cells. Laser confocal microscopy and

Identifiers

PMID40458672
PMCPMC12127665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.