ArticleOphthalmology science
Repeatability of Fractal Analysis in OCT Angiography of the Macula and Optic Nerve Head.
Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the repeatability of OCT angiography (OCTA) vessel density measurements using fractal analysis in the macula and optic nerve head (ONH) regions. Design: A prospective longitudinal observational cohort study. Participants: One hundred sixteen eyes from 71 primary open-angle glaucoma patients with valid macula OCTA scans and 91 eyes from 59 primary open-angle glaucoma patients with valid ONH OCTA scans, with 53 patients contributing scans for both regions. Methods: Participants underwent 5 OCTA imaging sessions at weekly intervals using the Spectralis spectral-domain OCT (Heidelberg Engineering). OCT angiography images were processed for fractal analysis focusing on small vessels (<25 μm in diameter) within Main Outcome Measures: Repeatability of OCTA vessel density quantified by fractal analysis and correlation with RNFL thickness. Results: One thousand three hundred twenty-eight macula OCTA scans from 269 visits and 801 ONH scans from 164 visits were included. Fractal analysis demonstrated high repeatability for vessel density measurements, with CoVs ranging from 0.4% to 0.9% in the macula and 0.7% to 1.8% in the ONH region. Full retina slabs exhibited the best repeatability in both regions, while DVC measurements in the ONH showed the highest variability (CoV = 1.8%). Moderate correlations between fractal parameters and RNFL thickness were observed in the ONH (SVC: rho = 0.65; NFLVP: rho = 0.67; Conclusions: High repeatability of OCTA vessel density measurements using fractal analysis was observed in the macula and ONH regions, supporting its potential utility in monitoring vascular changes in glaucoma. Future studies should investigate its diagnostic accuracy and ability to detect disease progression. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.