Evidence map›Paper›PMID 40458654›Full record

ArticleOTO open

Comparison of Hearing Phenotypes Among Children With Congenital Cytomegalovirus and Other Non-Cytomegalovirus Conditions.

Shi Liang, Emily Huang, Jordan Stout, Candace Winterton, Chong Zhang, Bridget F Dorsey, Angela Presson, Matthew Firpo, Albert Park

Abstract read
In one paragraph

Article in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shi LiangDepartment of Otolaryngology-Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah USA.ORCID 0000-0003-3195-1151
Emily HuangDepartment of Otolaryngology-Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah USA.
Jordan StoutDepartment of Otolaryngology-Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah USA.
Candace WintertonDepartment of Otolaryngology-Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah USA.
Chong ZhangDepartment of Internal Medicine University of Utah School of Medicine Salt Lake City Utah USA.
Bridget F DorseyDepartment of Otolaryngology-Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah USA.
Angela PressonDepartment of Internal Medicine University of Utah School of Medicine Salt Lake City Utah USA.
Matthew FirpoDepartment of Surgery University of Utah School of Medicine Salt Lake City Utah USA.ORCID 0000-0002-7983-3982
Albert ParkDepartment of Otolaryngology-Head and Neck Surgery University of Utah School of Medicine Salt Lake City Utah USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Hearing phenotype of the congenital cytomegalovirus (cCMV)-infected children with isolated sensorineural hearing loss (SNHL) may be distinct from other types of SNHL and may provide an alternative approach for diagnosis. Study Design: A retrospective cohort study. Setting: Hearing test results of SNHL patients between 2006 and 2022 at Primary Children's Hospital and patients with the following conditions were included: cCMV with isolated SNHL, connexin 26 mutation, enlarged vestibular aqueduct (EVA), and idiopathic. Methods: Using 1-way analysis of variance (ANOVA) tests, we compared each patient's first reliable hearing threshold from 250 to 4000 Hz. The area under the receiver-operating characteristic (AUROC) curves was calculated for hearing measures in the cCMV and idiopathic groups. The Youden index was then obtained to determine a prediction model for cCMV infection. Finally, plots of various parameters over time were evaluated to compare the cCMV and idiopathic groups. Results: A total of 72 patients were evaluated (cCMV: 19; connexin 26: 13; EVA: 24; and idiopathic: 16). The ANOVA test indicated the cCMV group tended to display greater hearing threshold asymmetry ( Conclusion: cCMV-infected children with isolated SNHL can present differently from the other causes of SNHL. The AUROC analysis suggests that a PTA difference greater than 58.6 dB may provide a prediction model to distinguish cCMV from other types of SNHL.

Indexed as

CMVcongenitalcytomegalovirushearing lossinfectionsensorineuralTORCH infection

Identifiers

PMID40458654
PMCPMC12128462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.