ArticlePediatrics open science
Maintenance Fluids for Late Preterm and Term Infants: Is it Time to Reconsider?
Article in Pediatrics open science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Hyponatremia in the neonatal intensive care unit: incidence, risk factors and effect on mortality.BMC pediatrics · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundLate preterm and term infants represent the majority of neonatal intensive care unit admissions globally, yet their fluid management remains underexplored.
methodsWe conducted a retrospective medical record review of 174 infants 34 weeks' gestational age or older who received dextrose-containing fluids shortly after birth. These infants had 24-hour serum sodium measurements at our institution between April 2018 and April 2021. We used regression models to analyze the correlation among intravenous fluid (IVF) intake per kilogram, gestational age, fluid balance (FB), weight change, and sodium status, adjusting for clinical factors.
resultsAt 24 hours, the average IVF intake was 57.2 mL/kg/d (SD 14.9). Of the infants, 130 (75%) had positive FB, 128 (74%) maintained or gained weight, 41 (24%) had sodium levels 132 mEq/L or less, and 68 (39%) had sodium 134 mEq/L or less. Positive FB was associated with weight gain and an increased likelihood of hyponatremia. Regression analysis showed a 0.07-mEq/L decrease in serum sodium (95% CI, -0.09 to -0.05;
conclusionPositive FB was common and strongly associated with hyponatremia in infants receiving standard IVF rates. These effects were most significant in term and unfed infants. Current fluid strategies may overestimate needs, particularly for term infants not receiving enteral feeds.
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Registered trials
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