SynthesisFrontiers in neurology2025
Usage, anti-inflammatory effect and safety of adjunctive acupuncture for cerebral infarction: an Apriori algorithm-based data mining and meta-analysis.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Data Mining of Acupuncture Prescriptions for Lateral Epicondylitis: A Literature-Based Analysis of Acupoint Patterns and Parameters.Journal of pain research · 2026Article
- Therapeutic Effect of Brain Awakening and Mind Opening Acupuncture Combined with Simiao Pill on Mice with Benign Prostatic Hyperplasia.Journal of inflammation research · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background purpose: The adjunctive effect of acupuncture for cerebral infarction (CI) remains inconsistent. We aimed to determine its anti-inflammatory effect, assess safety, and summarize the adjunctive use of acupuncture for CI. Methods: We identified qualified randomized controlled trials (RCTs) from eight literature databases. Frequency analysis and Apriori association analysis were conducted using SPSS Modeler 18.0 and SPSS 26.0 software. A meta-analysis was performed using Stata 17.0 software. The credibility of the meta-results and the certainty of the evidence was assessed using trial sequential analysis (TSA) and GRADE methods, respectively. Results: A total of 43 RCTs were included, comprising 3,861 participants. Acupuncture with intermittent treatment (5-7 times per week), a combination of multiple points and multiple meridians (an average of 9.35 points in each prescription), typically lasting for 2-4 weeks, was commonly used for CI treatment. Meta-analysis indicated that the adjunctive use of acupuncture reduced levels of TNF-α (SMD = -1.36; 95% CI -1.51 to -1.20, Conclusion: Intermittent acupuncture treatment lasting at least 2 w was commonly used for CI patients, typically involving multiple acupuncture points and meridians. Acupuncture demonstrated an anti-inflammatory effect in the treatment of CI. However, due to the low quality of the existing literature, high-quality randomized controlled trials (RCTs) are required to confirm these results in the future. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42017078583.
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