ArticleCureus2025
Calcitonin-Secreting Neuroendocrine Tumor of the Lung: A Diagnostic Dilemma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcitonin is primarily secreted by parafollicular C cells of the thyroid, with significantly elevated levels serving as the primary serum marker for medullary thyroid carcinoma. However, ectopic calcitonin secretion, though rare, has been reported in neuroendocrine tumors arising in extra-thyroidal sites such as the lung, breast, prostate, liver, and thymus. This can pose diagnostic challenges due to the immunohistochemical similarity between ectopic calcitonin-secreting neuroendocrine tumors and medullary thyroid carcinoma, particularly in patients with coexisting thyroid lesions. Here, we present a rare case of a calcitonin-secreting neuroendocrine tumor of the lung, aiming to enhance diagnostic awareness and highlight the potential for elevated serum calcitonin due to ectopic secretion from an extrathyroidal source.
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