ArticleCureus2025
Effects of Extracorporeal Shockwave Therapy on Wound Healing in Rats.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- [Shock waves as a preventive impulse : New approaches to reducing surgical and postoperative complications, including tissue regeneration].Orthopadie (Heidelberg, Germany) · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWound healing remains a major challenge in orthopedic surgeries involving thin soft-tissue injuries, such as calcaneal fractures and open wounds. Recent advancements, such as negative pressure wound therapy, have demonstrated efficacy but have practical limitations, such as patient immobility and fall risk, restricting their broader application. Extracorporeal shockwave therapy, recognized by the International Society for Medical Shockwave Treatment, has shown potential in treating complex wounds, ulcers, and burns. However, the mechanism through which extracorporeal shockwave therapy accelerates wound healing is still unclear. In this study, we aimed to investigate the effects of extracorporeal shockwave therapy on wound healing using a rat model.
methodsWe examined the effects of extracorporeal shockwave therapy on wound healing in a Sprague-Dawley rat model. Extracorporeal shockwave therapy was applied to the wound area using a cylindrical device, and histological evaluations, including immunohistochemical staining and real-time polymerase chain reaction analysis, were conducted to assess the effect of extracorporeal shockwave therapy on angiogenesis and tissue repair.
resultsAlthough no significant differences were found in wound contraction or vascular endothelial growth factor R2 (VEGFR2), CD31, or transforming growth factor-β1 (TGF-β1) expression, the histological analysis revealed increased vascularization and tissue regeneration in the extracorporeal shockwave therapy-treated group compared with those in the control group. On day 3, the number of blood vessels and area of CD31-positive cells were significantly higher in the extracorporeal shockwave therapy group than in the control group, with a continued increase in TGF-β1-positive cell count by day 7.
conclusionsThese findings suggest that extracorporeal shockwave therapy may enhance early wound healing by promoting angiogenesis and collagen production. Further research is needed to optimize extracorporeal shockwave therapy protocols and investigate their long-term effects on wound healing.
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