ReviewCureus2025
Role of Cardiac Rehabilitation in Heart Failure With Preserved Ejection Fraction (HFpEF): A Systematic Review of Clinical and Functional Outcomes.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review evaluates the role of exercise-based rehabilitation in heart failure with preserved ejection fraction (HFpEF) by synthesizing findings from high-quality meta-analyses. A comprehensive literature search was conducted following PRISMA guidelines, identifying six meta-analyses that examined the effects of structured exercise programs, including aerobic training, resistance training, inspiratory muscle training, and supervised rehabilitation. The findings consistently demonstrate significant improvements in functional capacity, with notable increases in peak oxygen uptake (VO₂ max) and 6-minute walk test (6MWT) distance. Quality of life measures, including the Minnesota Living With Heart Failure Questionnaire (MLWHFQ) and the SF-36 physical function domain, also showed meaningful enhancements. However, the impact of exercise on diastolic function and left ventricular remodeling remains inconclusive, with limited improvements in echocardiographic parameters such as the E/A ratio and E/e' ratio. The study selection process ensured the inclusion of only meta-analyses synthesizing randomized controlled trials (RCTs), providing a high level of evidence while minimizing biases associated with individual trials. Despite variability in exercise modalities, intervention duration, and patient characteristics, the overall findings support the integration of structured exercise programs into HFpEF management strategies. Further research is needed to explore long-term myocardial adaptations, optimal training regimens, and potential synergies between exercise therapy and pharmacological interventions to enhance clinical outcomes.
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Registered trials
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